tert-butyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate

Base Information

• Chemical Name: tert-butyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate
• CAS No.: 167484-91-5
• Molecular Formula: C17H23FN2O2
• Molecular Weight: 306.38
• Hs Code.: 2933990090
• Mol file: 167484-91-5.mol

Synonyms:tert-butyl 5-fluorospiro[1,2-dihydroindole-3,4'-piperidine]-1'-carboxylate;

Chemical Property of tert-butyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate

Chemical Property:

• Boiling Point: 424.6±45.0 °C(Predicted)
• PKA: 5.31±0.20(Predicted)
• Flash Point: 210.604oC
• PSA: 41.57000
• Density: 1.20±0.1 g/cm3(Predicted)
• LogP: 3.59580
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate

There total 3 articles about tert-butyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl-5-fluorospiro[indole-3,4'-piperidine]-1'-carboxylate (1279815-77-8) → tert-butyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate (167484-91-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 10 - 20 ℃; for 0.5h;

Reference yield:

tert-butyl 4-(methoxymethylene)piperidine-1-carboxylate (138022-91-0) → tert-butyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate (167484-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / acetonitrile; ethanol; tert-butyl methyl ether / 6.17 h / 20 - 50 °C

2: sodium tetrahydroborate / ethanol / 0.5 h / 10 - 20 °C

With sodium tetrahydroborate; trifluoroacetic acid; In ethanol; tert-butyl methyl ether; acetonitrile;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → tert-butyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate (167484-91-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; diethyl ether / 1.5 h / -10 - 5 °C

1.2: 2 h / -20 - 20 °C

2.1: trifluoroacetic acid / acetonitrile; ethanol; tert-butyl methyl ether / 6.17 h / 20 - 50 °C

3.1: sodium tetrahydroborate / ethanol / 0.5 h / 10 - 20 °C

With sodium tetrahydroborate; n-butyllithium; trifluoroacetic acid; In diethyl ether; ethanol; hexane; tert-butyl methyl ether; acetonitrile;

upstream raw materials:

tert-butyl 4-(methoxymethylene)piperidine-1-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

tert-butyl-5-fluorospiro[indole-3,4'-piperidine]-1'-carboxylate

Downstream raw materials:

(2-chloro-4-pyridyl)-[1'-[(E)-3-(3,4-difluorophenyl)allyl]-5-fluoro-spiro[indoline-3,4'-piperidine]-1-yl]methanone

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