(3aR,4S,7R,7aS)-2-(((1R,2S)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)Methyl)cyclohexyl)Methyl)hexahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione

Base Information

Chemical Name:(3aR,4S,7R,7aS)-2-(((1R,2S)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)Methyl)cyclohexyl)Methyl)hexahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione
CAS No.:139563-20-5
Molecular Formula:(x)C₄H₆O₆*C₂₈H₃₆N₄O₂S
Molecular Weight:492.67604
Hs Code.:
Mol file:139563-20-5.mol

Synonyms:(3aR,4S,7R,7aS)-2-(((1R,2S)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)Methyl)cyclohexyl)Methyl)hexahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione

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Chemical Property of (3aR,4S,7R,7aS)-2-(((1R,2S)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)Methyl)cyclohexyl)Methyl)hexahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione

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Technology Process of (3aR,4S,7R,7aS)-2-(((1R,2S)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)Methyl)cyclohexyl)Methyl)hexahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione

There total 6 articles about (3aR,4S,7R,7aS)-2-(((1R,2S)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)Methyl)cyclohexyl)Methyl)hexahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 194861-74-0,367514-87-2,1318074-25-7
lurasidone

: 147-71-7,138508-61-9
D-tartaric acid

: 139563-20-5
(3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione tartrate

Guidance literature:: In methanol; at 40 - 50 ℃; for 0.0833333h;

Reference yield:

: 3-(4-{[(1R,2R)-2-(nitromethyl)cyclohexyl]methyl}piperazin-1-yl)-1,2-benzisothiazole

: 139563-20-5
(3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione tartrate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / methanol; water; acetic acid / 6 h / 20 °C / 7500.75 Torr

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 120 °C / Inert atmosphere

3: methanol / 0.08 h / 40 - 50 °C

With hydrogen; potassium carbonate; In methanol; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 3-(4-{[(1R,2R)-2-(nitromethyl)cyclohexyl]methyl}piperazin-1-yl)-1,2-benzisothiazole (+)-O,O'-di-p-toluoyl-D-tartrate

: 139563-20-5
(3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione tartrate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / dichloromethane; water / 0 h

2: hydrogen / methanol; water; acetic acid / 6 h / 20 °C / 7500.75 Torr

3: potassium carbonate / N,N-dimethyl-formamide / 18 h / 120 °C / Inert atmosphere

4: methanol / 0.08 h / 40 - 50 °C

With hydrogen; potassium carbonate; sodium hydroxide; In methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;