4'-Hydroxy-3'-iodo-biphenyl-4-carbonitrile

Base Information

Chemical Name:4'-Hydroxy-3'-iodo-biphenyl-4-carbonitrile
CAS No.:460746-47-8
Molecular Formula:C13H8INO
Molecular Weight:321.117
Hs Code.:2926909090
European Community (EC) Number:696-505-4
DSSTox Substance ID:DTXSID90438712
Nikkaji Number:J2.316.289J
Wikidata:Q72484547
Mol file:460746-47-8.mol

Synonyms:460746-47-8;4'-Hydroxy-3'-iodo-biphenyl-4-carbonitrile;4-(4-hydroxy-3-iodophenyl)benzonitrile;4'-Hydroxy-3'-iodo-[1,1'-biphenyl]-4-carbonitrile;MFCD06796628;4'-hydroxy-3'-iodo[1,1'-biphenyl]-4-carbonitrile;C13H8INO;SCHEMBL2785702;AMY7366;DTXSID90438712;GGJLASJZXUIMAG-UHFFFAOYSA-N;AKOS015962778;AC-9294;SS-4452;SY238858;3'-Iodo-4'-hydroxybiphenyl-4-carbonitrile;CS-0039208;FT-0714776;3'-Iodo-4'-hydroxy-1,1'-biphenyl-4-carbonitrile;4'-hydroxy-3'-iodo-1,1'-biphenyl-4-carbonitrile;4'-hydroxy-3'-iodo [1,1'-biphenyl]-4-carbonitrile;4 inverted exclamation mark -Hydroxy-3 inverted exclamation mark -iodobiphenyl-4-carbonitrile

Suppliers and Price of 4'-Hydroxy-3'-iodo-biphenyl-4-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4''-Hydroxy-3''-iodobiphenyl-4-carbonitrile(TechnicalGrade;containsDiiodide(H005080))
1g
$ 135.00

Matrix Scientific
4-(4-Hydroxy-3-iodophenyl)benzonitrile >97%
1g
$ 487.00

Matrix Scientific
4-(4-Hydroxy-3-iodophenyl)benzonitrile >97%
500mg
$ 390.00

Crysdot
4'-Hydroxy-3'-iodo-[1,1'-biphenyl]-4-carbonitrile 97%
5g
$ 535.00

Crysdot
4'-Hydroxy-3'-iodo-[1,1'-biphenyl]-4-carbonitrile 97%
25g
$ 1604.00

Crysdot
4'-Hydroxy-3'-iodo-[1,1'-biphenyl]-4-carbonitrile 97%
10g
$ 871.00

Chemenu
4-(4-Hydroxy-3-iodophenyl)benzonitrile 95+%
10g
$ 823.00

Chemenu
4-(4-Hydroxy-3-iodophenyl)benzonitrile 95+%
25g
$ 1515.00

Chemenu
4-(4-Hydroxy-3-iodophenyl)benzonitrile 95+%
1g
$ 184.00

Chemenu
4-(4-Hydroxy-3-iodophenyl)benzonitrile 95+%
5g
$ 505.00

Total 13 raw suppliers

Chemical Property of 4'-Hydroxy-3'-iodo-biphenyl-4-carbonitrile

Chemical Property:

Melting Point:166-167℃
Boiling Point:392.9±37.0 °C(Predicted)
PKA:8.03±0.31(Predicted)
PSA：44.02000
Density:1.81
LogP:3.53548
Storage Temp.:2-8°C(protect from light)
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:320.96506
Heavy Atom Count:16
Complexity:277

Purity/Quality:

97% ^*data from raw suppliers

4''-Hydroxy-3''-iodobiphenyl-4-carbonitrile(TechnicalGrade;containsDiiodide(H005080)) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C#N)C2=CC(=C(C=C2)O)I
Uses 4''-Hydroxy-3''-iodobiphenyl-4-carbonitrile is the major component of the byproduct in the synthesis of 4''-Hydroxy-3'',5''-diiodo-[1,1''-biphenyl]-4-carbonitrile (H005080), which is a useful building block compound, and has been used in the preparation of plasminogen activator inhibitor antagonists.

Technology Process of 4'-Hydroxy-3'-iodo-biphenyl-4-carbonitrile

There total 2 articles about 4'-Hydroxy-3'-iodo-biphenyl-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 19812-93-2
4-Cyano-4'-hydroxybiphenyl

: 460746-47-8
4'-hydroxy-3'-iodo[1,1'-biphenyl]-4-carbonitrile

Guidance literature:: With N-iodo-succinimide; sulfuric acid; In acetic acid; at 20 ℃; stereoselective reaction; Inert atmosphere;
DOI:10.1021/op049809c

Reference yield: 40.0%

: 19812-93-2
4-Cyano-4'-hydroxybiphenyl

: sodium thiosulfate

: 460746-47-8
4'-hydroxy-3'-iodo[1,1'-biphenyl]-4-carbonitrile

Guidance literature:: With sodium hydroxide; sodium iodide; In methanol;

Reference yield: 95.0%

: 927-74-2
3-Butyn-1-ol

: 460746-47-8
4'-hydroxy-3'-iodo[1,1'-biphenyl]-4-carbonitrile

: 460746-48-9
4-[2-(2-hydroxyethyl)-1-benzofuran-5-yl]benzonitrile

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; Heating;
DOI:10.1016/j.bmcl.2003.11.032