Ethyl 4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Base Information

Chemical Name:Ethyl 4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate
CAS No.:853109-70-3
Molecular Formula:C₁₀H₁₂ClNO₃
Molecular Weight:229.663
Hs Code.:2933399090
DSSTox Substance ID:DTXSID20470504
Wikidata:Q82298617
Mol file:853109-70-3.mol

Synonyms:853109-70-3;Ethyl 4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate;4-CHLORO-1,5-DIMETHYL-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER;ethyl 4-chloro-1,5-dimethyl-6-oxopyridine-3-carboxylate;4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid ethyl ester;SCHEMBL391397;DTXSID20470504;LRPZMBUONONUPF-UHFFFAOYSA-N;Ethyl4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate;MFCD09031523;AKOS015965509;AS-73561;CS-0061583;FT-0742328;Y10759

Suppliers and Price of Ethyl 4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
Ethyl4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate
250mg
$ 544.40

Alichem
Ethyl4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate
1g
$ 615.44

Alichem
Ethyl4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate
250mg
$ 315.12

American Custom Chemicals Corporation
4-CHLORO-1,5-DIMETHYL-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 95.00%
5MG
$ 504.83

Chemenu
ethyl4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate 95%
1g
$ 729.00

Crysdot
Ethyl4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate 95+%
250mg
$ 396.00

Total 8 raw suppliers

Chemical Property of Ethyl 4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Chemical Property:

PSA：48.30000
LogP:1.52380
Storage Temp.:2-8°C
XLogP3:1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:229.0505709
Heavy Atom Count:15
Complexity:371

Purity/Quality:

95% ^*data from raw suppliers

Ethyl4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CN(C(=O)C(=C1Cl)C)C

Technology Process of Ethyl 4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate

There total 1 articles about Ethyl 4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 853106-90-8
ethyl 4-hydroxy-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate

: 853109-70-3
ethyl 4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Guidance literature:: With trichlorophosphate; In toluene; at 110 ℃; for 3h;

Reference yield:

: 853109-70-3
ethyl 4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate

: 4-(4-bromo-2-fluoro-phenylamino)-1,5-dimethyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid ethoxy-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. LiOH / tetrahydrofuran; methanol / 0.5 h / 20 °C

2.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: tetrahydrofuran; hexane / 17.5 h / -78 - 20 °C

3.1: EDCI; HOBt / dimethylformamide / 20 °C

3.2: Et₃N / dimethylformamide / 20 °C

With lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm050834y

Reference yield:

: 853109-70-3
ethyl 4-chloro-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate

: 4-(4-bromo-2-fluoro-phenylamino)-1,5-dimethyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid (2-hydroxy-ethoxy)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. LiOH / tetrahydrofuran; methanol / 0.5 h / 20 °C

2.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: tetrahydrofuran; hexane / 17.5 h / -78 - 20 °C

3.1: EDCI; HOBt / dimethylformamide / 3 h / 20 °C

3.2: Et₃N / dimethylformamide / 2 h / 20 °C

4.1: aq. HCl / tetrahydrofuran; ethanol / 1 h / 20 °C

With hydrogenchloride; lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm050834y