4-Ethyl hydrogen 1-methyl-1h-pyrazole-4,5-dicarboxylate , 97%

Base Information

• Chemical Name: 4-Ethyl hydrogen 1-methyl-1h-pyrazole-4,5-dicarboxylate , 97%
• CAS No.: 81303-65-3
• Molecular Formula: C8H10N2O4
• Molecular Weight: 198.178
• Hs Code.: 2933199090
• Mol file: 81303-65-3.mol

Synonyms:1-Methyl-1H-pyrazole-4,5-dicarboxylic acid 4-ethyl ester;2-methyl-2H-pyrazole-3,4-dicarboxylic acid 4-ethyl ester;4-ETHYL HYDROGEN 1-METHYL-1H-PYRAZOLE-4,5-DICARBOXYLATE;

Chemical Property of 4-Ethyl hydrogen 1-methyl-1h-pyrazole-4,5-dicarboxylate , 97%

Chemical Property:

• PSA: 81.42000
• LogP: 0.29500

Purity/Quality:

97% ^*data from raw suppliers

4-(Ethoxycarbonyl)-1-methyl-1H-pyrazole-5-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Statements: 22-36/37/38
• Safety Statements: 22-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Ethyl hydrogen 1-methyl-1h-pyrazole-4,5-dicarboxylate , 97%

There total 4 articles about 4-Ethyl hydrogen 1-methyl-1h-pyrazole-4,5-dicarboxylate , 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-methyl-2H-pyrazole-3,4-dicarboxylic acid diethyl ester (10514-61-1) → 4-(ethoxycarbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid (81303-65-3)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; ethanol; water; at -6 - -4 ℃; for 3.08333h; Concentration; Temperature; Time; Inert atmosphere;

Reference yield:

2-[1-(dimethylamino)methylidene]-3-oxosuccinic acid diethyl ester (130187-88-1) → 4-(ethoxycarbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid (81303-65-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethanol; water / 2 h / 60 °C / Inert atmosphere

2.1: sodium hydroxide; water / 0.5 h / Reflux

2.2: 0.5 h / 20 °C

With hydrogenchloride; water; sodium hydroxide; In ethanol; water;

Reference yield:

2-dimethylaminomethylene-3-oxo-succinic acid diethyl ester → 4-(ethoxycarbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid (81303-65-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethanol; water / 60 °C / Inert atmosphere

2.1: sodium hydroxide; water / 1 h / Reflux

2.2: 0.5 h

With hydrogenchloride; water; sodium hydroxide; In ethanol; water;

upstream raw materials:

2-methyl-2H-pyrazole-3,4-dicarboxylic acid diethyl ester

2-[1-(dimethylamino)methylidene]-3-oxosuccinic acid diethyl ester

(Z)-diethyl 2-((2-([tert-butoxy]carbonyl)-2-methylhydrazinyl)methylene)-3-oxosuccinate

Downstream raw materials:

5-(6-Cyano-2-phenyl-imidazo[1,2-a]pyridin-7-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

4-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (6-bromo-2-phenyl-imidazo[1,2-a]pyridin-7-yl)-amide

5-(6-bromo-2-phenyl-imidazo[1,2-a]pyridin-7-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

5-(6-bromo-2-phenyl-imidazo[1,2-a]pyridin-7-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid