N-(2,2-Difluoroethyl)-4-(6-fluoro-3-oxo-1H-pyrazolo[4,3-c]cinnolin-2(3H)-yl)benzamide

Base Information

Chemical Name:N-(2,2-Difluoroethyl)-4-(6-fluoro-3-oxo-1H-pyrazolo[4,3-c]cinnolin-2(3H)-yl)benzamide
CAS No.:763142-16-1
Molecular Formula:C₁₈H₁₂F₃N₅O₂
Molecular Weight:387.321
Hs Code.:2933990090
UNII:MNK3B6VR65
DSSTox Substance ID:DTXSID60432702
Wikidata:Q82246811
Mol file:763142-16-1.mol

Synonyms:763142-16-1;N-(2,2-Difluoroethyl)-4-(6-fluoro-3-oxo-1H-pyrazolo[4,3-c]cinnolin-2(3H)-yl)benzamide;MNK3B6VR65;N-(2,2-difluoroethyl)-4-(6-fluoro-3-oxo-1H-pyrazolo[4,3-c]cinnolin-2-yl)benzamide;N-(2,2-Difluoroethyl)-4-(6-fluoro-3-oxo-1H-pyrazolo(4,3-C)cinnolin-2(3H)-yl)benzamide;4-(6-Fluoro-3-oxo-1,3-dihydro-pyrazolo(4,3-C)cinnolin-2-yl)-N- (2,2-difluoro-ethyl)-benzamide;Benzamide, N-(2,2-difluoroethyl)-4-(6-fluoro-1,3-dihydro-3-oxo-2H-pyrazolo(4,3-C)cinnolin-2-yl)-;N-(2,2-difluoro-ethyl)-4-(6-fluoro-3-oxo-1,3-dihydro-pyrazolo[4,3-c]cinnolin-2-yl)-benzamide;N-(2,2-Difluoroethyl)-4-(6-fluoro-1,3-dihydro-3-oxo-2H-pyrazolo(4,3-C)cinnolin-2-yl)benzamide;RhuDex;UNII-MNK3B6VR65;SCHEMBL235747;SCHEMBL4100405;DTXSID60432702;ZQYASCYCJOQFIE-UHFFFAOYSA-M;N-(2,2-difluoro-ethyl)-4-(6-fluoro-3-oxo-1,3-dihydro-pyrazolo[4,3-c]cin nolin-2-yl)-benzamide;N-(2,2-difluoroethyl)-4-(6-fluoro-3-oxo-1,3-dihydro-2H-pyrazolo[4,3-c]cinnolin-2-yl)benzamide;N-(2,2-DIFLUOROETHYL)-4-{6-FLUORO-3-OXO-1H,2H,3H-PYRAZOLO[4,3-C]CINNOLIN-2-YL}BENZAMIDE

Suppliers and Price of N-(2,2-Difluoroethyl)-4-(6-fluoro-3-oxo-1H-pyrazolo[4,3-c]cinnolin-2(3H)-yl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
N-(2,2-Difluoroethyl)-4-(6-fluoro-3-oxo-1H-pyrazolo[4,3-c]cinnolin-2(3H)-yl)benzamide 95+%
1g
$ 772.00

Chemenu
N-(2,2-difluoroethyl)-4-(6-fluoro-3-oxo-1,3-dihydro-2H-pyrazolo[4,3-c]cinnolin-2-yl)benzamide 95%
1g
$ 729.00

American Custom Chemicals Corporation
N-(2,2-DIFLUOROETHYL)-4-(6-FLUORO-3-OXO-1H-PYRAZOLO[4,3-C]CINNOLIN-2(3H)-YL)BENZAMIDE 95.00%
5MG
$ 504.25

Alichem
N-(2,2-Difluoroethyl)-4-(6-fluoro-3-oxo-1H-pyrazolo[4,3-c]cinnolin-2(3H)-yl)benzamide
1g
$ 671.96

Total 3 raw suppliers

Chemical Property of N-(2,2-Difluoroethyl)-4-(6-fluoro-3-oxo-1H-pyrazolo[4,3-c]cinnolin-2(3H)-yl)benzamide

Chemical Property:

PSA：92.67000
LogP:2.78690
Storage Temp.:2-8°C
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:387.09430913
Heavy Atom Count:28
Complexity:602

Purity/Quality:

97% ^*data from raw suppliers

N-(2,2-Difluoroethyl)-4-(6-fluoro-3-oxo-1H-pyrazolo[4,3-c]cinnolin-2(3H)-yl)benzamide 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C3C(=NN=C2C(=C1)F)C(=O)N(N3)C4=CC=C(C=C4)C(=O)NCC(F)F
Recent ClinicalTrials:Study Evaluating the Pharmacokinetic Profile of Novel Formulations of RHUDEX?

Technology Process of N-(2,2-Difluoroethyl)-4-(6-fluoro-3-oxo-1H-pyrazolo[4,3-c]cinnolin-2(3H)-yl)benzamide

There total 2 articles about N-(2,2-Difluoroethyl)-4-(6-fluoro-3-oxo-1H-pyrazolo[4,3-c]cinnolin-2(3H)-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 430-67-1
2,2-difluorethylamine

: 763142-16-1
4-(6-fluoro-3-oxo-1,3-dihydro-2H-pyrazolo[4,3-c]cinnolin-2-yl)-N-(2,2-difluoro-ethylyl)-benzamide

Guidance literature:: 4-(6-fluoro-3-oxo-1,3-dihydro-2H-pyrazolo[4,3-c]cinnolin-2-yl)benzoic acid; With thionyl chloride; for 2h; Heating / reflux;

2,2-difluorethylamine; With N-ethyl-N,N-diisopropylamine; In ISOPROPYLAMIDE; at 20 ℃; for 0.0666667 - 0.0833333h;