4-Fluoro-3-methoxybenzenesulfonyl chloride

Base Information

• Chemical Name: 4-Fluoro-3-methoxybenzenesulfonyl chloride
• CAS No.: 887266-97-9
• Molecular Formula: C7H6ClFO3S
• Molecular Weight: 224.64
• Hs Code.: 2909309090
• European Community (EC) Number: 861-670-5
• DSSTox Substance ID: DTXSID10382642
• Wikidata: Q82173991
• Mol file: 887266-97-9.mol

Synonyms:887266-97-9;4-fluoro-3-methoxybenzenesulfonyl chloride;4-fluoro-3-methoxybenzenesulphonyl chloride;4-fluoro-3-methoxybenzene-1-sulfonyl chloride;4-fluoro-3-methoxy-benzenesulfonyl Chloride;SCHEMBL1816396;DTXSID10382642;AJHUCNUEJYHKMR-UHFFFAOYSA-N;GS3090;MFCD07368708;AKOS006220685;4-Fluoro-3-methoxyphenylsulfonyl chloride;PS-10876;4-fluoro-3-methoxybenzene-1-sulfonylchloride;EN300-171976;W16362;4-fluoro-3-methoxybenzenesulfonyl chloride, AldrichCPR;Z1203133412

Chemical Property of 4-Fluoro-3-methoxybenzenesulfonyl chloride

Chemical Property:

• PSA: 51.75000
• LogP: 2.84260
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 223.9710211
• Heavy Atom Count: 13
• Complexity: 261

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoro-3-methoxybenzenesulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)S(=O)(=O)Cl)F

Technology Process of 4-Fluoro-3-methoxybenzenesulfonyl chloride

There total 1 articles about 4-Fluoro-3-methoxybenzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluoro-3-methoxyaniline (64465-53-8) → 4-fluoro-3-methoxybenzene-1-sulfonyl chloride (887266-97-9)

Guidance literature:

4-fluoro-3-methoxyaniline; With hydrogenchloride; acetic acid; sodium nitrite; In water; at 0 ℃; for 0.166667h;

With sulfur dioxide; acetic acid; copper dichloride; In water; at 0 - 20 ℃;

Reference yield: 99.0%

4-fluoro-3-methoxybenzene-1-sulfonyl chloride (887266-97-9) + (R)-2-((6-bromo-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)isoindoline-1,3-dione → (S)-2-((6-bromo-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)isoindoline-1,3-dione

Guidance literature:

With pyridine; at 50 ℃;

Reference yield: 86.7%

1-methyl-piperazine (109-01-3) + 4-fluoro-3-methoxybenzene-1-sulfonyl chloride (887266-97-9) → 1-((4-fluoro-3-methoxyphenyl)sulfonyl)-4-methylpiperazine

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃; for 2h;

upstream raw materials:

4-fluoro-3-methoxyaniline