(R)-2-((R)-6,7-Dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide

Base Information

Chemical Name:(R)-2-((R)-6,7-Dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide
CAS No.:913358-93-7
Molecular Formula:C29H31F3N2O3
Molecular Weight:549.033
Hs Code.:
Mol file:913358-93-7.mol

Synonyms:AlMorexant (hydrochloride);(alphaR,1S)-3,4-Dihydro-6,7-dimethoxy-N-methyl-alpha-phenyl-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-2(1H)-isoquinolineacetamide monohydrochloride;Almorexant HCI;(R)-2-((S)-1-(4-(trifluoromethyl)phenethyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide hydrochloride

Suppliers and Price of (R)-2-((R)-6,7-Dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AlmorexantHydrochloride
50 mg
$ 665.00

DC Chemicals
AlmorexantHCl(Act-078573) >98%
1 g
$ 2500.00

DC Chemicals
AlmorexantHCl(Act-078573) >98%
250 mg
$ 1400.00

DC Chemicals
AlmorexantHCl(Act-078573) >98%
100 mg
$ 700.00

Crysdot
Almorexanthydrochloride 98+%
50mg
$ 599.00

Crysdot
Almorexanthydrochloride 98+%
100mg
$ 1015.00

Crysdot
Almorexanthydrochloride 98+%
5mg
$ 102.00

Crysdot
Almorexanthydrochloride 98+%
10mg
$ 172.00

ChemScene
Almorexanthydrochloride 99.88%
100mg
$ 1440.00

ChemScene
Almorexanthydrochloride 99.88%
10mg
$ 240.00

Total 21 raw suppliers

Chemical Property of (R)-2-((R)-6,7-Dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide

Chemical Property:

PSA：50.80000
LogP:6.87270
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

AlmorexantHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Almorexant Hydrochloride is an orally active orexin antagonist (OX1 and OX2 dual receptor antagonist) used in the treatment of insomnia.

Technology Process of (R)-2-((R)-6,7-Dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide

There total 3 articles about (R)-2-((R)-6,7-Dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1296659-30-7
(1S)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline hydrochloride

: 871224-68-9
(S)-2-(methylamino)-2-oxo-1-phenylethyl 4-methylbenzenesulfonate

: 913358-93-7
almorexant hydrochloride

Guidance literature:: (1S)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline hydrochloride; With sodium carbonate; In butanone; at 20 ℃; for 0.166667h;

(S)-2-(methylamino)-2-oxo-1-phenylethyl 4-methylbenzenesulfonate; In butanone; for 16h; Reflux;

With hydrogenchloride; In ethyl acetate; at 60 ℃; for 1h; Product distribution / selectivity; Reflux;

Reference yield:

: 871224-64-5
almorexant

: 913358-93-7
almorexant hydrochloride

Guidance literature:: With hydrogenchloride; In methylisobutylketone (MIBK); water;

Reference yield:

: 871224-68-9
(S)-2-(methylamino)-2-oxo-1-phenylethyl 4-methylbenzenesulfonate

: 1169801-28-8
(S)-6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-1,2,3,4-tetrahydroisoquinoline acetate

: 913358-93-7
almorexant hydrochloride

Guidance literature:: (S)-6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-1,2,3,4-tetrahydroisoquinoline acetate; With sodium hydroxide; In 4-methyl-2-pentanone; at 20 ℃;

(S)-2-(methylamino)-2-oxo-1-phenylethyl 4-methylbenzenesulfonate; With potassium carbonate; sodium hydroxide; In water; 4-methyl-2-pentanone; at 70 - 90 ℃;

With hydrogenchloride; In water; 4-methyl-2-pentanone;