Propanoic acid, 3-fluoro-2-(fluoromethyl)-2-methyl-

Base Information

• Chemical Name: Propanoic acid, 3-fluoro-2-(fluoromethyl)-2-methyl-
• CAS No.: 1208092-05-0
• Molecular Formula: C5H8F2O2
• Molecular Weight: 138.114
• Mol file: 1208092-05-0.mol

Synonyms:Propanoic acid, 3-fluoro-2-(fluoromethyl)-2-methyl-;3-fluoro-2-(fluoroMethyl)-2-Methylpropanoic acid

Chemical Property of Propanoic acid, 3-fluoro-2-(fluoromethyl)-2-methyl-

Chemical Property:

• Boiling Point: 218.4±25.0 °C(Predicted)
• PKA: 3.08±0.15(Predicted)
• PSA: 37.30000
• Density: 1.184±0.06 g/cm3(Predicted)
• LogP: 1.01630

Purity/Quality:

98+% ^*data from raw suppliers

3-Fluoro-2-(fluoromethyl)-2-methylpropanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanoic acid, 3-fluoro-2-(fluoromethyl)-2-methyl-

There total 3 articles about Propanoic acid, 3-fluoro-2-(fluoromethyl)-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 3-fluoro-2-(fluoromethyl)-2-methylpropanoate → 3-fluoro-2-(fluoromethyl)-2-methylpropanoic acid (1208092-05-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 12h; under 775.743 Torr;

Reference yield:

benzyl 2,2-bis(hydroxylmethyl)propionate (179388-73-9) → 3-fluoro-2-(fluoromethyl)-2-methylpropanoic acid (1208092-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 12 h / -20 - 20 °C

2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 12 h / 775.74 Torr

With diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; In dichloromethane; ethyl acetate;

Reference yield:

→ 3-fluoro-2-(fluoromethyl)-2-methylpropanoic acid (1208092-05-0)

Guidance literature:

upstream raw materials:

benzyl 2,2-bis(hydroxylmethyl)propionate

Refernces

• 1、 -. "ORGANIC COMPOUNDS". Page/Page column 95. . Retrieved 2010/04/06.