6-Ethoxy-4-hydroxy-quinoline-3-carboxylic acid

Base Information

• Chemical Name: 6-Ethoxy-4-hydroxy-quinoline-3-carboxylic acid
• CAS No.: 303121-10-0
• Molecular Formula: C₁₂H₁₁NO₄
• Molecular Weight: 233.224
• Hs Code.: 2933499090
• Mol file: 303121-10-0.mol

Synonyms:OTAVA-BB BB0109850005;AURORA 17942;6-ETHOXY-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID;AKOS BBS-00008771;OTAVA-BB 0109850005

Chemical Property of 6-Ethoxy-4-hydroxy-quinoline-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 9.73E-08mmHg at 25°C
• Boiling Point: 418.1°C at 760 mmHg
• Flash Point: 206.7°C
• PSA: 79.65000
• Density: 1.349g/cm³
• LogP: 2.03730

Purity/Quality:

98%min ^*data from raw suppliers

6-Ethoxy-4-hydroxy-quinoline-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Ethoxy-4-hydroxy-quinoline-3-carboxylic acid

There total 3 articles about 6-Ethoxy-4-hydroxy-quinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 6-ethoxy-4-hydroxyquinoline-3-carboxylate (127285-44-3,303121-08-6) → 6-ethoxy-4-hydroxy-quinoline-3-carboxylic acid (303121-10-0)

Guidance literature:

With sodium hydroxide;

Reference yield:

2-(4-ethoxy-anilinomethylene)-propanedioic acid diethyl ester (103976-28-9) → 6-ethoxy-4-hydroxy-quinoline-3-carboxylic acid (303121-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl ether

2: aqueous NaOH

With sodium hydroxide; diphenylether;

Reference yield:

4-Ethoxyaniline (156-43-4) → 6-ethoxy-4-hydroxy-quinoline-3-carboxylic acid (303121-10-0)

Guidance literature:

Multi-step reaction with 3 steps

2: diphenyl ether

3: aqueous NaOH

With sodium hydroxide; diphenylether;

upstream raw materials:

ethyl 6-ethoxy-4-hydroxyquinoline-3-carboxylate

2-(4-ethoxy-anilinomethylene)-propanedioic acid diethyl ester

4-Ethoxyaniline

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