7,8-Dihydroisoquinolin-5(6H)-one, hydrochloride

Base Information

• Chemical Name: 7,8-Dihydroisoquinolin-5(6H)-one, hydrochloride
• CAS No.: 103441-65-2
• Molecular Formula: C9H10ClNO
• Molecular Weight: 183.6348
• Hs Code.: 2933499090
• Mol file: 103441-65-2.mol

Synonyms:7,8-Dihydro-6H-isochinolin-5-on,Hydrochlorid;7,8-DIHYDROISOQUINOLIN-5(6H)-ONE HCL;7,8-dihydro-5(6H)-isoquinolinone hydrochloride;7,8-Dihydro-6H-isoquinolin-5-one monohydrochloride;7,8-DIHYDRO-6H-ISOQUINOLIN-5-ONE HYDROCHLORIDE;7,8-Dihydroisoquinolin-5(6H)-one hydrochloride;

Chemical Property of 7,8-Dihydroisoquinolin-5(6H)-one, hydrochloride

Chemical Property:

• Melting Point: 235-236 °C
• PSA: 29.96000
• LogP: 2.40260
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

7,8-Dihydroisoquinolin-5(6H)-oneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7,8-Dihydroisoquinolin-5(6H)-one, hydrochloride

There total 2 articles about 7,8-Dihydroisoquinolin-5(6H)-one, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

7,8-dihydroisoquinolin-5(6H)-one oxime (115787-46-7) → 7,8-dihydro-5(6H)-isoquinolinone hydrochloride (103441-65-2)

Guidance literature:

With hydrogenchloride; In water; acetone; for 15h; Heating / reflux;

Reference yield:

5,6,7,8-tetrahydroisoquinoline (36556-06-6) → 7,8-dihydro-5(6H)-isoquinolinone hydrochloride (103441-65-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 18 h / 20 °C

1.2: 18 h / 0 - 20 °C

2.1: hydrogenchloride; water / acetone / 12 h / 80 °C

With hydrogenchloride; potassium tert-butylate; water; In tetrahydrofuran; acetone;

Reference yield:

7,8-dihydro-5(6H)-isoquinolinone hydrochloride (103441-65-2) → 7,8-dihydroisoquinolin-5(6H)-one (21917-86-2)

Guidance literature:

With sodium hydrogencarbonate; In water;

upstream raw materials:

7,8-dihydroisoquinolin-5(6H)-one oxime

5,6,7,8-tetrahydroisoquinoline

Downstream raw materials:

7,8-dihydroisoquinolin-5(6H)-one

Refernces

• 1、 -. "CYCLOALKANOPYRIDINE DERIVATIVE". Page/Page column 34. . Retrieved 2010/11/24.