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Technology Process of Tesevatinib

Tesevatinib

Base Information
  • Chemical Name:Tesevatinib
  • CAS No.:781613-23-8
  • Deprecated CAS:874286-84-7,950774-05-7
  • Molecular Formula:C24H25Cl2FN4O2
  • Molecular Weight:491.393
  • Hs Code.:
  • UNII:F6XM2TN5A1
  • DSSTox Substance ID:DTXSID201336925
  • Wikipedia:Tesevatinib
  • Wikidata:Q27089251
  • NCI Thesaurus Code:C62496
  • Pharos Ligand ID:9JH8LGBMTUGL,9JHJ2DHTH79U
  • ChEMBL ID:CHEMBL3544983
  • Mol file:781613-23-8.mol
Tesevatinib

Synonyms:EXEL-7647;N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,6aS)-2-methyloctahydrocyclopenta(c)pyrrol-5-yl)methoxy)-4-quinazolinamine;tesevatinib;XL-647;XL647

Suppliers and Price of Tesevatinib
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • DC Chemicals
  • xl647 >98%
  • 100 mg
  • $ 750.00
  • Crysdot
  • XL647 98+%
  • 5mg
  • $ 311.00
  • Crysdot
  • XL647 98+%
  • 10mg
  • $ 558.00
  • ChemScene
  • Tesevatinib 99.21%
  • 10mg
  • $ 648.00
  • ChemScene
  • Tesevatinib 99.21%
  • 5mg
  • $ 360.00
  • Chemenu
  • N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine 98%
  • 50mg
  • $ 926.00
  • Cayman Chemical
  • XL647
  • 10mg
  • $ 553.00
  • Cayman Chemical
  • XL647
  • 5mg
  • $ 296.00
  • Cayman Chemical
  • XL647
  • 1mg
  • $ 79.00
Total 25 raw suppliers
Chemical Property of Tesevatinib
Chemical Property:
  • Boiling Point:567.9±50.0 °C(Predicted) 
  • PKA:10.16±0.40(Predicted) 
  • PSA：59.51000 
  • Density:1.356 
  • LogP:5.80540 
  • XLogP3:5.8
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:7
  • Rotatable Bond Count:6
  • Exact Mass:490.1338596
  • Heavy Atom Count:33
  • Complexity:652
Purity/Quality:

99%, *data from raw suppliers

xl647 >98% *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CN1CC2CC(CC2C1)COC3=C(C=C4C(=C3)N=CN=C4NC5=C(C(=C(C=C5)Cl)Cl)F)OC
  • Isomeric SMILES:CN1C[C@H]2CC(C[C@H]2C1)COC3=C(C=C4C(=C3)N=CN=C4NC5=C(C(=C(C=C5)Cl)Cl)F)OC
  • Recent ClinicalTrials:Study of the Efficacy and Safety of Tesevatinib in Subjects With ADPKD
  • Uses XL 647 is a potent and selective EGFR phosphorylation inhibitor and may be used in the treatment of patients suffering from lung cancer. Orally available, multi-target tyrosine kinase inhibitor.
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