Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester
• CAS No.: 1147422-00-1
• Molecular Formula: C12H22N2O2
• Molecular Weight: 226.319
• Hs Code.: 2933990090
• Mol file: 1147422-00-1.mol

Synonyms:Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester;1-Boc-1H-octahydropyrrolo[3,2-c]pyridine;1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid, octahydro-, 1,1-diMethylethyl ester

Chemical Property of Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester

Chemical Property:

• PSA: 41.57000
• LogP: 1.87200
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-1H-octahydropyrrolo[3,2-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester

There total 4 articles about Octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 1H-pyrrolo[3,2-c]pyridine-1-carboxylate (148760-75-2) → tert-butyl octahydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate (1147422-00-1,848410-13-9)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; acetic acid; In 2-methoxy-ethanol; at 70 ℃; for 24h; under 15001.5 Torr;

Reference yield: 99.0%

5-benzyl-octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester (1147421-99-5) → tert-butyl octahydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate (1147422-00-1,848410-13-9)

Guidance literature:

With hydrogen; 5% palladium hydroxide on activated carbon; In methanol; ethanol; at 20 ℃; for 10h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl octahydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate (1147422-00-1,848410-13-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 6 h / 0 °C

2: acetic acid; 10 wt% Pd(OH)2 on carbon; hydrogen / 2-methoxy-ethanol / 24 h / 70 °C / 15001.5 Torr

With 10 wt% Pd(OH)2 on carbon; hydrogen; acetic acid; triethylamine; In 2-methoxy-ethanol;

upstream raw materials:

5-benzyl-octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester

di-tert-butyl dicarbonate

tert-butyl 1H-pyrrolo[3,2-c]pyridine-1-carboxylate

5-azaindole

Downstream raw materials:

5-benzyl 1-tert-butyl hexahydro-1H-pyrrolo[3,2-c]pyridine-1,5(6H)-dicarboxylate

benzyl hexahydro-1H-pyrrolo[3,2-c]pyridine-5(6H)-carboxylate hydrochloride

benzyl 1-methylhexahydro-1H-pyrrolo[3,2-c]pyridine-5(6H)-carboxylate

tert-butyl 5-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)octahydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate