4-(1-(2-(Pyrrolidin-1-yl)ethyl)-4-(tetrahydro-2h-pyran-4-yl)-1h-imidazol-2-yl)piperidine

Base Information

• Chemical Name: 4-(1-(2-(Pyrrolidin-1-yl)ethyl)-4-(tetrahydro-2h-pyran-4-yl)-1h-imidazol-2-yl)piperidine
• CAS No.: 1295521-50-4
• Molecular Formula: C19H32N4O
• Molecular Weight: 332.48
• Mol file: 1295521-50-4.mol

Synonyms:LSN2988032;4-(1-(2-(pyrrolidin-1-yl)ethyl)-4-(tetrahydro-2H-pyran-4-yl)-1H-iMidazol-2-yl)piperidine

Chemical Property of 4-(1-(2-(Pyrrolidin-1-yl)ethyl)-4-(tetrahydro-2h-pyran-4-yl)-1h-imidazol-2-yl)piperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1-(2-(Pyrrolidin-1-yl)ethyl)-4-(tetrahydro-2h-pyran-4-yl)-1h-imidazol-2-yl)piperidine

There total 19 articles about 4-(1-(2-(Pyrrolidin-1-yl)ethyl)-4-(tetrahydro-2h-pyran-4-yl)-1h-imidazol-2-yl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tert-butyl 4-(4-(tetrahydro-2H-pyran-4-yl)-1-(2-(pyrrolidin-1-yl)ethyl)-1H-imidazol-2-yl)piperidine-1-carboxylate (1295520-35-2) → 4-(1-(2-pyrrolidin-1-yl-ethyl)-4-(tetrahydro-pyran-4-yl)-1H-imidazol-2-yl)-piperidine (1295521-50-4)

Guidance literature:

tert-butyl 4-(4-(tetrahydro-2H-pyran-4-yl)-1-(2-(pyrrolidin-1-yl)ethyl)-1H-imidazol-2-yl)piperidine-1-carboxylate; With hydrogenchloride; In isopropyl alcohol; at 50 ℃; for 6h;

With sodium hydroxide; In water; pH=12;

Reference yield:

4-(prop-2-en-1-yloxy)but-1-yne (75405-45-7) → 4-(1-(2-pyrrolidin-1-yl-ethyl)-4-(tetrahydro-pyran-4-yl)-1H-imidazol-2-yl)-piperidine (1295521-50-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: copper(l) chloride; lithium chloride; potassium acetate / N,N-dimethyl-formamide / 0 °C

2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 16 h

3.1: sodium carbonate / dimethyl sulfoxide / 0.08 h

3.2: 0.75 h / 75 - 80 °C

4.1: hydrogen / palladium on carbon / ethanol / 32 h / 65 - 70 °C / 10343.2 Torr

5.1: hydrogenchloride / isopropyl alcohol / 6 h / 50 °C

5.2: pH 12

With hydrogenchloride; hydrogen; potassium acetate; sodium carbonate; copper(l) chloride; lithium chloride; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on carbon; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyran (287944-16-5) → 4-(1-(2-pyrrolidin-1-yl-ethyl)-4-(tetrahydro-pyran-4-yl)-1H-imidazol-2-yl)-piperidine (1295521-50-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium carbonate / dimethyl sulfoxide / 0.08 h

1.2: 0.75 h / 75 - 80 °C

2.1: hydrogen / palladium on carbon / ethanol / 32 h / 65 - 70 °C / 10343.2 Torr

3.1: hydrogenchloride / isopropyl alcohol / 6 h / 50 °C

3.2: pH 12

With hydrogenchloride; hydrogen; sodium carbonate; palladium on carbon; In ethanol; dimethyl sulfoxide; isopropyl alcohol;

upstream raw materials:

tetrahydropyran-4-carboxylic acid methyl ester

4-(prop-2-en-1-yloxy)but-1-yne

tetrahydro-2H-pyran-4-carboxylic acid

1-(tetrahydro-2H-pyran-4-yl)ethan-1-one