3-(2-chlorophenyl)-6-fluoro-4-oxo-3,4-dihydroquinazol ine-2-carb

Base Information

Chemical Name:3-(2-chlorophenyl)-6-fluoro-4-oxo-3,4-dihydroquinazol ine-2-carb
CAS No.:217942-80-8
Molecular Formula:C15H8ClFN2O2
Molecular Weight:302.692
Hs Code.:
Mol file:217942-80-8.mol

Synonyms:3-(2-chlorophenyl)-6-fluoro-4-oxo-3,4-dihydroquinazol ine-2-carb;3-(2-chlorophenyl)-6-fluoro-4-oxo-3,4-dihydroquinazol ine-2-carbalde hyde

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Chemical Property of 3-(2-chlorophenyl)-6-fluoro-4-oxo-3,4-dihydroquinazol ine-2-carb

Chemical Property:

PSA：51.96000
LogP:2.99070

Purity/Quality:

Safty Information:

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Hazard Codes:

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Technology Process of 3-(2-chlorophenyl)-6-fluoro-4-oxo-3,4-dihydroquinazol ine-2-carb

There total 3 articles about 3-(2-chlorophenyl)-6-fluoro-4-oxo-3,4-dihydroquinazol ine-2-carb which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 217943-01-6
3-(2-chlorophenyl)-6-fluoro-2-(2-(dimethylamino)vinyl)-3,4-dihydroquinazolin-4-one

: 217942-80-8
3-(2-chlorophenyl)-6-fluoro-3,4-dihydroquinazolin-4-one-2-carboxaldehyde

Guidance literature:: With sodium periodate; In tetrahydrofuran; water; at 20 ℃; for 1h; pH=7;
DOI:10.1021/jm000522p

Reference yield:

: 3-(2-chloro-phenyl)-6-fluoro-2-(2-dimethylamino-vinyl)-3,4-dihydro-quinazolin-4-one

: 217942-80-8
3-(2-chlorophenyl)-6-fluoro-3,4-dihydroquinazolin-4-one-2-carboxaldehyde

Guidance literature:: With sodium periodate; In tetrahydrofuran;

Reference yield:

: 49579-12-6
3-(2-chloro-phenyl)-6-fluoro-2-methyl-3H-quinazolin-4-one

: 217942-80-8
3-(2-chlorophenyl)-6-fluoro-3,4-dihydroquinazolin-4-one-2-carboxaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / dimethylformamide / 24 h / 140 °C

2: 97 percent / NaIO₄ / tetrahydrofuran; H₂O / 1 h / 20 °C / pH 7

With sodium periodate; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm000522p