2,4-Morpholinedicarboxylic acid 4-tert-butyl 2-ethyl ester

Base Information

• Chemical Name: 2,4-Morpholinedicarboxylic acid 4-tert-butyl 2-ethyl ester
• CAS No.: 768371-16-0
• Molecular Formula: C12H21NO5
• Molecular Weight: 259.30
• Hs Code.: 2934999090
• Mol file: 768371-16-0.mol

Synonyms:2,4-Morpholinedicarboxylic acid 4-tert-butyl 2-ethyl ester

Chemical Property of 2,4-Morpholinedicarboxylic acid 4-tert-butyl 2-ethyl ester

Chemical Property:

• Boiling Point: 329℃
• PKA: -2.71±0.40(Predicted)
• Flash Point: 153℃
• PSA: 65.07000
• Density: 1.128
• LogP: 1.12330
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-boc-2-morpholinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Morpholinedicarboxylic acid 4-tert-butyl 2-ethyl ester

There total 1 articles about 2,4-Morpholinedicarboxylic acid 4-tert-butyl 2-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + ethyl 4-benzylmorpholine-2-carboxylate (135072-32-1,107904-08-5) → 4-(tert-butyl) 2-ethyl morpholine-2,4-dicarboxylate (768371-16-0)

Guidance literature:

With 2,5-dihydrotoluene; palladium 10% on activated carbon; In ethanol; at 88 ℃; for 34h;

Reference yield:

4-(tert-butyl) 2-ethyl morpholine-2,4-dicarboxylate (768371-16-0) → 2-(methoxymethyl)morpholine (156121-15-2,157791-20-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol / 3 h / 0 - 20 °C

2: sodium hydride / 4 h

3: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 0 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; sodium hydride; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

4-(tert-butyl) 2-ethyl morpholine-2,4-dicarboxylate (768371-16-0) → (±)-tert-butyl 2-(3-(2-benzyl-6-(methylcarbamoyl)isonicotinamido)propyl)-2-methylmorpholine-4-carboxylate

Guidance literature:

Multi-step reaction with 9 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C

1.2: 1 h / -78 °C

2.1: lithium borohydride / 2-methyltetrahydrofuran / Cooling with ice; Inert atmosphere

3.1: Dess-Martin periodane / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

4.1: toluene / 20 °C

5.1: ammonium formate; 5%-palladium/activated carbon / ethanol / 6 h / 85 °C

6.1: lithium borohydride / tetrahydrofuran / Cooling with ice

6.2: Cooling with ice

7.1: triethylamine; methanesulfonyl chloride / dichloromethane / 5 h / 20 °C / Cooling with ice

7.2: 4 h / 70 °C

8.1: triphenylphosphine / tetrahydrofuran; water / 20 °C

9.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C

With lithium borohydride; 5%-palladium/activated carbon; ammonium formate; Dess-Martin periodane; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; lithium hexamethyldisilazane; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

di-tert-butyl dicarbonate

ethyl 4-benzylmorpholine-2-carboxylate

Downstream raw materials:

2-(methoxymethyl)morpholine