1-Benzyl-4-n-boc-amino-piperidine-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-Benzyl-4-n-boc-amino-piperidine-4-carboxylic acid methyl ester
• CAS No.: 294180-37-3
• Molecular Formula: C19H28N2O4
• Molecular Weight: 348.44
• Hs Code.: 2933399090
• Mol file: 294180-37-3.mol

Synonyms:1-BENZYL-4-N-BOC-AMINO-PIPERIDINE-4-CARBOXYLIC ACID METHYL ESTER ;1-Benzyl-4-tert-butoxycarbonylamino-piperidine-4-carboxylic acid methyl ester;1-BENZYL-4-N-BOC-AMINO-ISONIPECOTIC ACID METHYL ESTER;Methyl 1-Benzyl-4-(Boc-amino)piperidine-4-carboxylate

Chemical Property of 1-Benzyl-4-n-boc-amino-piperidine-4-carboxylic acid methyl ester

Chemical Property:

• Vapor Pressure: 3.49E-08mmHg at 25°C
• Boiling Point: 447°C at 760 mmHg
• Flash Point: 224.1°C
• PSA: 67.87000
• Density: 1.14g/cm³
• LogP: 3.04770
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Benzyl-4-N-boc-amino-isonipecoticAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Benzyl-4-n-boc-amino-piperidine-4-carboxylic acid methyl ester

There total 5 articles about 1-Benzyl-4-n-boc-amino-piperidine-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H26N2O4 + diazomethyl-trimethyl-silane (18107-18-1) → 1-benzyl-4-[(tert-butyloxycarbonyl)amino]-4-(methoxycarbonyl)piperidine (294180-37-3)

Guidance literature:

In methanol; dichloromethane; at 15 ℃; for 3h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + methyl 4-amino-1-benzylpiperidine-4-carboxylate (57611-57-1) → 1-benzyl-4-[(tert-butyloxycarbonyl)amino]-4-(methoxycarbonyl)piperidine (294180-37-3)

Guidance literature:

With sodium hydroxide; In dichloromethane;

Reference yield:

8-benzyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione (28936-94-9) → 1-benzyl-4-[(tert-butyloxycarbonyl)amino]-4-(methoxycarbonyl)piperidine (294180-37-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide; water / 24 h / 100 °C

2: sodium hydroxide / water; 1,4-dioxane / 3 h / 15 °C

3: methanol; dichloromethane / 3 h / 15 °C

With water; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water;

upstream raw materials:

di-tert-butyl dicarbonate

methyl 4-amino-1-benzylpiperidine-4-carboxylate

8-benzyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione

1-benzyl-4-amino-4-piperidinecarboxylic acid

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