Benzenepropanoic acid, .alpha.,.beta.-dibroMo-4-fluoro-, ethyl e

Base Information

• Chemical Name: Benzenepropanoic acid, .alpha.,.beta.-dibroMo-4-fluoro-, ethyl e
• CAS No.: 42122-47-4
• Molecular Formula: C11H11Br2FO2
• Molecular Weight: 354
• Mol file: 42122-47-4.mol

Synonyms:ETHYL 2,3-DIBROMO-3-(4-FLUOROPHENYL)PROPANOATE;BENZENEPROPANOICACID,.ALPHA.,.BETA.-DIBROMO-4-FLUORO-,ETHYLESTER;

Chemical Property of Benzenepropanoic acid, .alpha.,.beta.-dibroMo-4-fluoro-, ethyl e

Chemical Property:

• PSA: 26.30000
• LogP: 3.58830

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanoic acid, .alpha.,.beta.-dibroMo-4-fluoro-, ethyl e

There total 2 articles about Benzenepropanoic acid, .alpha.,.beta.-dibroMo-4-fluoro-, ethyl e which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

ethyl 4-fluorocinnamate (24393-50-8,136265-10-6,352-03-4) → 2,3-dibromo-3-(4-fluoro-phenyl)-propionic acid ethyl ester (42122-47-4)

Guidance literature:

With bromine; In tetrachloromethane; at 0 ℃;

Reference yield:

ethyl 4-fluorocinnamate (136265-10-6,352-03-4,24393-50-8) → 2,3-dibromo-3-(4-fluoro-phenyl)-propionic acid ethyl ester (42122-47-4)

Guidance literature:

With bromine; In tetrachloromethane; Heating;

DOI:10.1016/0584-8539(82)80085-8

Reference yield: 6.0%

2,3-dibromo-3-(4-fluoro-phenyl)-propionic acid ethyl ester (42122-47-4) → 3-(4-flurophenyl)prop-2-ynoic acid (706-06-9)

Guidance literature:

2,3-dibromo-3-(4-fluoro-phenyl)-propionic acid ethyl ester; With potassium hydroxide; ethanol; at 40 ℃; for 3h; Heating / reflux;

With hydrogenchloride; In ethanol; water;

With sulfuric acid; In water; at 0 - 20 ℃; for 0.333333h; pH=1;

upstream raw materials:

ethyl 4-fluorocinnamate

ethyl 4-fluorocinnamate

Downstream raw materials:

ethyl 3-(4-fluorophenyl)propiolate

3-(4-flurophenyl)prop-2-ynoic acid