4-[(benzyloxy)Methyl]-3,3-difluoropiperidine

Base Information

• Chemical Name: 4-[(benzyloxy)Methyl]-3,3-difluoropiperidine
• CAS No.: 1206540-49-9
• Molecular Formula: C13H17F2NO
• Molecular Weight: 241
• Mol file: 1206540-49-9.mol

Synonyms:4-[(benzyloxy)Methyl]-3,3-difluoropiperidine

Chemical Property of 4-[(benzyloxy)Methyl]-3,3-difluoropiperidine

Chemical Property:

• Melting Point: 44.1 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))
• Boiling Point: 304.3±42.0 °C(Predicted)
• PKA: 6.48±0.10(Predicted)
• PSA: 21.26000
• Density: 1.14±0.1 g/cm3(Predicted)
• LogP: 2.77680

Purity/Quality:

99%min ^*data from raw suppliers

4-[(BENZYLOXY)METHYL]-3,3-DIFLUOROPIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[(benzyloxy)Methyl]-3,3-difluoropiperidine

There total 1 articles about 4-[(benzyloxy)Methyl]-3,3-difluoropiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-(benzyloxymethyl)-3,3-difluoro-2-piperidinone (1206540-46-6) → 4-((benzyloxy)methyl)-3,3-difluoropiperidine (1206540-49-9)

Guidance literature:

4-(benzyloxymethyl)-3,3-difluoro-2-piperidinone; With borane-THF; In tetrahydrofuran; at 0 ℃; Inert atmosphere; Reflux;

With palladium 10% on activated carbon; In methanol; at 0 - 20 ℃;

DOI:10.1021/jo902164z

Reference yield: 72.0%

4-((benzyloxy)methyl)-3,3-difluoropiperidine (1206540-49-9) → 4-(benzyloxymethyl)-3,3-difluoro-1-(trifluoroacetyl)piperidine (1206540-52-4)

Guidance literature:

With trifluoroacetic anhydride; In ethyl acetate; at 0 - 20 ℃;

DOI:10.1021/jo902164z

Reference yield:

4-((benzyloxy)methyl)-3,3-difluoropiperidine (1206540-49-9) → 3-(4-((benzyloxy)methyl)-3,3-difluoropiperidin-1-yl)-4-(4-chloro-1H-pyrazol-1-yl)pyridine

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / toluene / 3 h / 120 °C / Microwave irradiation

2: toluene-4-sulfonic acid / isopropyl alcohol / 6 h / 150 °C / Microwave irradiation

With palladium diacetate; toluene-4-sulfonic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In isopropyl alcohol; toluene;

upstream raw materials:

4-(benzyloxymethyl)-3,3-difluoro-2-piperidinone

Downstream raw materials:

4-(benzyloxymethyl)-3,3-difluoro-1-(trifluoroacetyl)piperidine

Refernces