3-DEAZA-DA CEP

Base Information

Chemical Name:3-DEAZA-DA CEP
CAS No.:666257-76-7
Molecular Formula:C48H53N6O7P
Molecular Weight:856.94
Hs Code.:
Mol file:666257-76-7.mol

Synonyms:3-DEAZA-DA CEP;N6-Benzoyl-3-deaza-2-deoxy-5-O-DMT-3-methyladenosine 3-CE phosphoramidite

Suppliers and Price of 3-DEAZA-DA CEP

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
N6-Benzoyl-3-deaza-2'-deoxy-5'-O-DMT-3-methyladenosine 3'-CE phosphoramidite
80 mg
$ 944.00

Biosynth Carbosynth
N6-Benzoyl-3-deaza-2'-deoxy-5'-O-DMT-3-methyladenosine 3'-CE phosphoramidite
80 ug
$ 944.00

Biosynth Carbosynth
N6-Benzoyl-3-deaza-2'-deoxy-5'-O-DMT-3-methyladenosine 3'-CE phosphoramidite
40 mg
$ 540.00

Biosynth Carbosynth
N6-Benzoyl-3-deaza-2'-deoxy-5'-O-DMT-3-methyladenosine 3'-CE phosphoramidite
40 ug
$ 540.00

American Custom Chemicals Corporation
3-DEAZA-2'-DEOXYADENOSINE 3'-CE PHOSPHORAMIDITE 95.00%
5MG
$ 502.16

Total 6 raw suppliers

Chemical Property of 3-DEAZA-DA CEP

Chemical Property:

PSA：155.81000
LogP:9.73118

Purity/Quality:

97% ^*data from raw suppliers

N6-Benzoyl-3-deaza-2'-deoxy-5'-O-DMT-3-methyladenosine 3'-CE phosphoramidite ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-DEAZA-DA CEP

There total 15 articles about 3-DEAZA-DA CEP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 143556-17-6
5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-N⁶-benzoyl-3-deazaadenosine

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 666257-76-7
2'-deoxy-3'-O-[(N,N-diisopropylamino)-(β-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)-N⁶-benzoyl-3-deazaadenosine

Guidance literature:: With N,N-dimethyl-ethanamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/ja0588454

Reference yield:

: 143354-17-0
2'-deoxy-N⁶-benzoyl-3-deazaadenosine

: 666257-76-7
2'-deoxy-3'-O-[(N,N-diisopropylamino)-(β-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)-N⁶-benzoyl-3-deazaadenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 20 mg / pyridine / 18 h / 20 °C

2: 80 percent / N-ethyldimethylamine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; N,N-dimethyl-ethanamine; In dichloromethane;
DOI:10.1021/ja0588454

Reference yield:

: 886227-20-9
5-iodo-1-[2',3',5'-O-tris(tert-butyldimethylsilyl)-β-D-ribofuranosyl]imidazole-4-carbonitrile

: 666257-76-7
2'-deoxy-3'-O-[(N,N-diisopropylamino)-(β-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)-N⁶-benzoyl-3-deazaadenosine

Guidance literature:: Multi-step reaction with 9 steps

1.1: Pd(PhCN)2Cl₂; Et₃N / acetonitrile / 20 h / 110 °C

1.2: 50 percent / NH₃; methanol / 14 h / 120 °C

2.1: 79 percent / Amberlite IRA 900 fluoride-form / toluene / 6 h / Heating

3.1: 81 percent / pyridine / 5 h / 20 °C

4.1: chlorotrimethylsilane; pyridine / 0.83 h / 0 °C

4.2: pyridine / 3.5 h / 0 - 20 °C

4.3: 93 percent / aq. NH₃ / 3 h / 20 °C

5.1: dimethylformamide / 4 h / 20 °C

6.1: 51 mg / α,α'-azo-isobutyronitrile; n-Bu3SnH / toluene / 3 h / 75 °C

7.1: Amberlite IRA 900 fluoride-form / toluene / 5 h / Heating

8.1: 20 mg / pyridine / 18 h / 20 °C

9.1: 80 percent / N-ethyldimethylamine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; bis(benzonitrile)palladium(II) dichloride; chloro-trimethyl-silane; N,N-dimethyl-ethanamine; Amberlite IRA 900 fluoride-form; azobisisobutyronitrile; tri-n-butyl-tin hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ja0588454