3-(2-Hydroxyethyl)piperazin-2-one

Base Information

• Chemical Name: 3-(2-Hydroxyethyl)piperazin-2-one
• CAS No.: 936940-62-4
• Molecular Formula: C6H12N2O2
• Molecular Weight: 144.173
• Hs Code.: 2933599090
• Mol file: 936940-62-4.mol

Synonyms:3-(2-hydroxyethyl)piperazin-2-one;UKRORGSYN-BB BBV-182545;3-(2-hydroxyethyl)piperazin-2-one(SALTDATA: FREE);3-(2-hydroxyethyl)piperazin-2-one hydrochloride

Chemical Property of 3-(2-Hydroxyethyl)piperazin-2-one

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.468
• Boiling Point: 411.606°C at 760 mmHg
• Flash Point: 202.732°C
• PSA: 61.36000
• Density: 1.108g/cm³
• LogP: -0.88560
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-(2-hydroxyethyl)piperazin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-Hydroxyethyl)piperazin-2-one

There total 1 articles about 3-(2-Hydroxyethyl)piperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 2-(3-oxopiperazin-2-yl)acetate (33422-35-4,686300-89-0) → 3-(2-hydroxyethyl)piperazin-2-one (936940-62-4)

Guidance literature:

ethyl 2-(3-oxopiperazin-2-yl)acetate; With lithium aluminium tetrahydride; In tetrahydrofuran; for 3.66667h; Heating / reflux;

With water; In tetrahydrofuran; for 0.5h;

Reference yield: 26.6%

3-(2-hydroxyethyl)piperazin-2-one (936940-62-4) + 7-chloro-5-methyl-2-{1-[4-(trifluoromethyl)phenyl]ethyl}pyrazolo[1,5-a]pyrimidine + trifluoroacetic acid (76-05-1) → 3-(2-hydroxyethyl)-4-(5-methyl-2-{1-[4-(trifluoromethyl)phenyl]ethyl}pyrazolo[1,5-a]pyrimidin-7-yl)piperazin-2-one trifluoroacetate

Guidance literature:

3-(2-hydroxyethyl)piperazin-2-one; 7-chloro-5-methyl-2-{1-[4-(trifluoromethyl)phenyl]ethyl}pyrazolo[1,5-a]pyrimidine; With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

3-(2-hydroxyethyl)piperazin-2-one (936940-62-4) + 2-(4-(4-cyano-3-methylphenoxy)phenyl)acetic acid → C22H23N3O4

Guidance literature:

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c00111

upstream raw materials:

ethyl 2-(3-oxopiperazin-2-yl)acetate

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