N-BIOTINYL-N'-MALEIMIDO-ETHYLENEDIAMINE

Base Information

• Chemical Name: N-BIOTINYL-N'-MALEIMIDO-ETHYLENEDIAMINE
• CAS No.: 139554-72-6
• Molecular Formula: C₁₆H₂₂N₄O₄S
• Molecular Weight: 366.441
• Mol file: 139554-72-6.mol

Synonyms:N-BIOTINYL-N'-MALEIMIDO-ETHYLENEDIAMINE;(3aS,4S,6aR)-N-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethyl]hexahydro-2-oxo-1H-thieno[3,4-d]iMidazole-4-pentanaMide;5-(2-Oxo-hexahydro-thieno[3,4-d]iMidazol-6-yl)-pentanoic acid [2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-aMide

Chemical Property of N-BIOTINYL-N'-MALEIMIDO-ETHYLENEDIAMINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 123-129°C
• Boiling Point: 743.543°C at 760 mmHg
• Flash Point: 403.48°C
• PSA: 132.91000
• Density: 1.313g/cm³
• LogP: 0.73980
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated)

Purity/Quality:

99% ^*data from raw suppliers

N-Biotinyl-N’-maleimido-ethylenediamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-BIOTINYL-N'-MALEIMIDO-ETHYLENEDIAMINE

There total 6 articles about N-BIOTINYL-N'-MALEIMIDO-ETHYLENEDIAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-(2-aminoethyl)-1H-pyrrole-2,5-dione (125923-10-6) + biotin (58-85-5,22879-79-4) → 1-(2-(D-biotinamido)ethyl)-1H-pyrrole-2,5-dione (139554-72-6)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1007/s10719-017-9785-4

Reference yield: 84.0%

N-(2-aminoethyl)maleimide trifluoroacetic acid salt (146474-00-2) + biotin N-Hydroxysuccinimide ester (35013-72-0) → 1-(2-(D-biotinamido)ethyl)-1H-pyrrole-2,5-dione (139554-72-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

Reference yield: 35.1%

biotin N-Hydroxysuccinimide ester (35013-72-0) + N-(2-aminoethyl)maleimide trifluoroacetate (146474-00-2) → 1-(2-(D-biotinamido)ethyl)-1H-pyrrole-2,5-dione (139554-72-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/acs.orglett.1c03145

upstream raw materials:

biotin

N-(2-aminoethyl)maleimide trifluoroacetic acid salt

biotin N-Hydroxysuccinimide ester

1-(2-aminoethyl)-1H-pyrrole-2,5-dione