3-Benzofuranacetic acid, 5-methoxy-, methyl ester

Base Information

• Chemical Name: 3-Benzofuranacetic acid, 5-methoxy-, methyl ester
• CAS No.: 118610-60-9
• Molecular Formula: C12H12O4
• Molecular Weight: 220.22
• Mol file: 118610-60-9.mol

Synonyms:5-methoxy-3-benzofuranacetic acid methylester;

Chemical Property of 3-Benzofuranacetic acid, 5-methoxy-, methyl ester

Chemical Property:

• PSA: 48.67000
• LogP: 2.15690

Purity/Quality:

>97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Benzofuranacetic acid, 5-methoxy-, methyl ester

There total 7 articles about 3-Benzofuranacetic acid, 5-methoxy-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

5-methoxy-benzofuran-3-one (39581-55-0) + methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) → methyl 2-(5-methoxybenzofuran-3-yl)acetate (118610-60-9)

Guidance literature:

In xylene; at 140 ℃; for 60h;

DOI:10.1021/ol702844g

Reference yield:

2,5-dimethoxybenzoyl chloride (17918-14-8) → methyl 2-(5-methoxybenzofuran-3-yl)acetate (118610-60-9)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether

2: gl. AcOH / 1.5 h

3: toluene / 50 h / Heating

With acetic acid; In diethyl ether; toluene;

DOI:10.1021/jm980076u

Reference yield:

2-Diazo-1-(2,5-dimethoxy-phenyl)-ethanone → methyl 2-(5-methoxybenzofuran-3-yl)acetate (118610-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: gl. AcOH / 1.5 h

2: toluene / 50 h / Heating

With acetic acid; In toluene;

DOI:10.1021/jm980076u

upstream raw materials:

5-methoxy-benzofuran-3-one

methyl (triphenylphosphoranylidene)acetate

2,5-dimethoxybenzoic acid

2,5-dimethoxybenzoyl chloride

Downstream raw materials:

(+/-)-methyl 2-(2,3-dihydro-5-methoxybenzofuran-3-yl)acetate

N,N-dimethyl-2-(5-methoxybenzofuran-3-yl)ethanamine