Benzeneacetic acid, 4-cyclopropyl-

Base Information

• Chemical Name: Benzeneacetic acid, 4-cyclopropyl-
• CAS No.: 40641-90-5
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• Hs Code.: 2916399090
• Mol file: 40641-90-5.mol

Synonyms:Benzeneacetic acid, 4-cyclopropyl-;4-Cyclopropylphenylacetic acid

Chemical Property of Benzeneacetic acid, 4-cyclopropyl-

Chemical Property:

• PSA: 37.30000
• LogP: 2.19110

Purity/Quality:

98% ^*data from raw suppliers

4-Cyclopropylphenylacetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, 4-cyclopropyl-

There total 8 articles about Benzeneacetic acid, 4-cyclopropyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl (4-cyclopropylphenyl)acetate (40641-92-7) → 2-(4-cyclopropylphenyl)acetic acid (40641-90-5)

Guidance literature:

With water; lithium hydroxide; In methanol; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2011.01.089

Reference yield: 98.0%

methyl 2-(4-cyclopropylphenyl)acetate (1097870-73-9) → 2-(4-cyclopropylphenyl)acetic acid (40641-90-5)

Guidance literature:

methyl 2-(4-cyclopropylphenyl)acetate; With lithium hydroxide; water; In tetrahydrofuran; methanol; at 20 ℃; for 4h;

With hydrogenchloride; In water; ethyl acetate; pH=3 - 4;

Reference yield: 90.0%

→ 2-(4-cyclopropylphenyl)acetic acid (40641-90-5)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃; for 16h;

upstream raw materials:

4-[(4-cyclopropyl-phenyl)-thioacetyl]-morpholine

ethyl (4-cyclopropylphenyl)acetate

methyl 2-(4-cyclopropylphenyl)acetate

Ethyl 4-bromophenylacetate

Downstream raw materials:

(R)-4-benzyl-3-(2-(4-cyclopropylphenyl)acetyl)oxazolidin-2-one

Refernces

• 1、 -. "T-TYPE CALCIUM CHANNEL BLOCKER". Paragraph 0191-0192; 0202-0203; 0239-0240. . Retrieved 2021/05/29.
• 2、 Reger, Thomas S.,Yang, Zhi-Qiang,Schlegel, Kelly-Ann S.,Shu, Youheng,Mattern, Christa,Cube, Rowena,Rittle, Kenneth E.,McGaughey, Georgia B.,Hartman, George D.,Tang, Cuyue,Ballard, Jeanine,Kuo, Yuhsin,Prueksaritanont, Thomayant,Nuss, Cindy E.,Doran, Scott M.,Fox, Steven V.,Garson, Susan L.,Li, Yuxing,Kraus, Richard L.,Uebele, Victor N.,Renger, John J.,Barrow, James C.. "Pyridyl amides as potent inhibitors of T-type calcium channels". supporting information; experimental part. p. 1692 - 1696. Retrieved 2011/05/11.