Carbamic acid, N-[2-[4-[[bis(1,1-dimethylethoxy)phosphinyl]oxy]-3-formylphenyl]-2-hydro xyethyl]-N-[6-(4-phenylbutoxy)hexyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, N-[2-[4-[[bis(1,1-dimethylethoxy)phosphinyl]oxy]-3-formylphenyl]-2-hydro xyethyl]-N-[6-(4-phenylbutoxy)hexyl]-, 1,1-dimethylethyl ester
• CAS No.: 917480-07-0
• Molecular Formula: C38H60NO9P
• Molecular Weight: 705.869
• Mol file: 917480-07-0.mol

Synonyms:tert-Butyl (2-(4-((di-tert-butoxyphosphoryl)oxy)-3-formylphenyl)-2-hydroxyethyl)(6-(4-phenylbutoxy)hexyl)carbamate;

Chemical Property of Carbamic acid, N-[2-[4-[[bis(1,1-dimethylethoxy)phosphinyl]oxy]-3-formylphenyl]-2-hydro xyethyl]-N-[6-(4-phenylbutoxy)hexyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, N-[2-[4-[[bis(1,1-dimethylethoxy)phosphinyl]oxy]-3-formylphenyl]-2-hydro xyethyl]-N-[6-(4-phenylbutoxy)hexyl]-, 1,1-dimethylethyl ester

There total 2 articles about Carbamic acid, N-[2-[4-[[bis(1,1-dimethylethoxy)phosphinyl]oxy]-3-formylphenyl]-2-hydro xyethyl]-N-[6-(4-phenylbutoxy)hexyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

[2-(3-formyl-4-hydroxy-phenyl)-2-hydroxy-ethyl]-[6-(4-phenyl-butoxy)-hexyl]-carbamic acid tert-butyl ester (917480-06-9) + di-tert-butyl phosphite (13086-84-5) → {2-[4-(di-tert-butoxy-phosphoryloxy)-3-formyl-phenyl]-2-hydroxy-ethyl}-[6-(4-phenyl-butoxy)-hexyl]-carbamic acid tert-butyl ester (917480-07-0)

Guidance literature:

di-tert-butyl phosphite; With Bromotrichloromethane; N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; In dichloromethane; water; ethyl acetate; at 0 - 20 ℃; for 2.08333h;

[2-(3-formyl-4-hydroxy-phenyl)-2-hydroxy-ethyl]-[6-(4-phenyl-butoxy)-hexyl]-carbamic acid tert-butyl ester; With dmap; In dichloromethane; water; at 20 ℃; for 1h;

Reference yield: 72.0%

[2-(3-formyl-4-hydroxy-phenyl)-2-hydroxy-ethyl]-[6-(4-phenyl-butoxy)-hexyl]-carbamic acid tert-butyl ester (917480-06-9) + di-tert-butyl phosphorobromidate (59346-65-5) → {2-[4-(di-tert-butoxy-phosphoryloxy)-3-formyl-phenyl]-2-hydroxy-ethyl}-[6-(4-phenyl-butoxy)-hexyl]-carbamic acid tert-butyl ester (917480-07-0)

Guidance literature:

With dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0 ℃; for 1.75h;

Reference yield: 75.0%

{2-[4-(di-tert-butoxy-phosphoryloxy)-3-formyl-phenyl]-2-hydroxy-ethyl}-[6-(4-phenyl-butoxy)-hexyl]-carbamic acid tert-butyl ester (917480-07-0) → {2-[4-(di-tert-butoxy-phosphoryloxy)-3-hydroxymethyl-phenyl]-2-hydroxy-ethyl}-[6-(4-phenyl-butoxy)-hexyl]-carbamic acid tert-butyl ester (917480-08-1)

Guidance literature:

{2-[4-(di-tert-butoxy-phosphoryloxy)-3-formyl-phenyl]-2-hydroxy-ethyl}-[6-(4-phenyl-butoxy)-hexyl]-carbamic acid tert-butyl ester; With sodium tetrahydroborate; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

With methanol; In tetrahydrofuran; at -78 - 0 ℃; for 4h;

upstream raw materials:

[2-(3-formyl-4-hydroxy-phenyl)-2-hydroxy-ethyl]-[6-(4-phenyl-butoxy)-hexyl]-carbamic acid tert-butyl ester

di-tert-butyl phosphorobromidate

di-tert-butyl phosphite

Downstream raw materials:

{2-[4-(di-tert-butoxy-phosphoryloxy)-3-hydroxymethyl-phenyl]-2-hydroxy-ethyl}-[6-(4-phenyl-butoxy)-hexyl]-carbamic acid tert-butyl ester

1-[[5-[1-hydroxy-2-[(t-butoxycarbonyl)[6-(4-phenylbutoxy)hexyl]amino]ethyl]-2-(di-tert-butylphosphoryloxy)benzyl]amino]acetic acid [[11β,16α]-[15,16-((R)-cyclohexylmethylene)bis(oxy)]-11-hydroxypregna-1,4-diene-3,20-dion-21-yl]ester