Boceprevir-d9

Base Information

Chemical Name:Boceprevir-d9
CAS No.:1256751-11-7
Molecular Formula:C27H36D9N5O5
Molecular Weight:528.613
Hs Code.:
Mol file:1256751-11-7.mol

Synonyms:Boceprevir-d9;(1R,2S,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[[1,1-di(methyl-d3)ethyl-2,2,2-d3]amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide

Suppliers and Price of Boceprevir-d9

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Boceprevir-d9
500ug
$ 1097.00

TRC
Boceprevir-d9
0.5mg
$ 730.00

Total 21 raw suppliers

Chemical Property of Boceprevir-d9

Chemical Property:

PSA：157.68000
LogP:3.78500
Storage Temp.:Refrigerator
Solubility.:DMSO, Methanol

Purity/Quality:

99% ^*data from raw suppliers

Boceprevir-d9 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A labelled NS3 serine protease inhibitor of hepatitis C virus.

Technology Process of Boceprevir-d9

There total 4 articles about Boceprevir-d9 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1373318-85-4
C₂₇H₃₈⁽²⁾H₉N₅O₅

: 1256751-11-7
[D₉]boceprevir

Guidance literature:: With dichloro-acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; toluene; at 0 ℃; for 20h; Inert atmosphere;
DOI:10.1002/jlcr.1960

Reference yield:

: (1R,2S,5S)-methyl 3-((S)-2-amino-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate hydrochloride

: 1256751-11-7
[D₉]boceprevir

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / dichloromethane / 0.5 h / 0 °C

1.2: 2.75 h / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; water / 7 h / 20 °C / Inert atmosphere

3.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 20 h / -20 - 20 °C / Inert atmosphere

4.1: dichloro-acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide; toluene / 20 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; dichloro-acetic acid; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1002/jlcr.1960

Reference yield:

: 1373318-83-2
C₂₀H₂₆⁽²⁾H₉N₃O₄

: 1256751-11-7
[D₉]boceprevir

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / tetrahydrofuran; water / 7 h / 20 °C / Inert atmosphere

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 20 h / -20 - 20 °C / Inert atmosphere

3: dichloro-acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide; toluene / 20 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; dichloro-acetic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1002/jlcr.1960