(S)-chroMan-3-aMine hydrochloride

Base Information

• Chemical Name: (S)-chroMan-3-aMine hydrochloride
• CAS No.: 59108-54-2
• Molecular Formula: C9H11NO
• Molecular Weight: 185.65068
• Hs Code.: 2932999099
• Mol file: 59108-54-2.mol

Synonyms:(S)-3,4-Dihydro-2H-1-benzopyran-3-amine;

Chemical Property of (S)-chroMan-3-aMine hydrochloride

Chemical Property:

• Melting Point: 241-242 °C (decomp)
• Boiling Point: 256.8±29.0 °C(Predicted)
• PKA: 7.49±0.20(Predicted)
• PSA: 35.25000
• Density: 1.106±0.06 g/cm3(Predicted)
• LogP: 2.45110

Purity/Quality:

98%min ^*data from raw suppliers

(S)-Chroman-3-amine hydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-chroMan-3-aMine hydrochloride

There total 3 articles about (S)-chroMan-3-aMine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

Benzyl-(S)-chroman-3-yl-amine; hydrochloride → (S)-chroman-3-amine (59108-54-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; Ambient temperature;

DOI:10.1021/jo980133r

Reference yield:

chroman-3-one (19090-04-1) → (S)-chroman-3-amine (59108-54-2) + (R)-3-aminochromane (59108-53-1)

Guidance literature:

With D-Glucose; glutamate dehydrogenase; D-Alanine; ω-transaminase from variant Arthrobacter citreus; PLP; nicotinamide adenine dinucleotide; lactate dehydrogenase; In aq. phosphate buffer; dimethyl sulfoxide; at 30 ℃; for 24h; pH=7; enantioselective reaction; Enzymatic reaction;

DOI:10.1021/cs400002d

Reference yield:

chroman-3-one (19090-04-1) → (S)-chroman-3-amine (59108-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) HOAc, 2.) NaCNBH₃ / 1.) THF, room temperature, 0.5 h, 2.) overnight

2: 84 percent / H₂ / Pd/C / methanol / Ambient temperature

With hydrogen; sodium cyanoborohydride; acetic acid; palladium on activated charcoal; In methanol;

DOI:10.1021/jo980133r

upstream raw materials:

chroman-3-one

Refernces

• 1、 Brisander, Magnus,Caldirola, Patrizia,Johansson, Anette M.,Hacksell, Uli. "Alkylation of Tricarbonylchromium-Stabilized Benzylic Anions of 3-(Dipropylamino)chroman". . p. 5362 - 5367. Retrieved 2007/10/03.