(R,S)-Boc-3-amino-2-(naphthalen-2-yl)-propionic acid

Base Information

Chemical Name:(R,S)-Boc-3-amino-2-(naphthalen-2-yl)-propionic acid
CAS No.:1310680-21-7
Molecular Formula:C18H21NO4
Molecular Weight:315.36364
Hs Code.:29225090
Mol file:1310680-21-7.mol

Synonyms:Boc-3-amino-2-(naphthalen-2-yl)-propionic acid;Boc-3-amino-2-(naphthalen-1-yl)-propionic acid;(R,S)-Boc-3-amino-2-(naphthalen-2-yl)-propionic acid;(R,S)-Boc-3-amino-2-(naphthalen-1-ylmethyl)-propionic acid≥ 97% (HPLC)

Suppliers and Price of (R,S)-Boc-3-amino-2-(naphthalen-2-yl)-propionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
3-((tert-Butoxycarbonyl)amino)-2-(naphthalen-1-yl)propanoicacid 95+%
1g
$ 371.00

Chemenu
3-((tert-Butoxycarbonyl)amino)-2-(naphthalen-1-yl)propanoicacid 95%
1g
$ 351.00

Acrotein
Boc-3-amino-2-(naphthalen-1-yl)-propionicacid 97%
0.25g
$ 160.97

Total 6 raw suppliers

Chemical Property of (R,S)-Boc-3-amino-2-(naphthalen-2-yl)-propionic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-((tert-Butoxycarbonyl)amino)-2-(naphthalen-1-yl)propanoicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R,S)-Boc-3-amino-2-(naphthalen-2-yl)-propionic acid

There total 8 articles about (R,S)-Boc-3-amino-2-(naphthalen-2-yl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 24424-99-5
di-tert-butyl dicarbonate

: (S)-(-)-3-amino-2-(α-naphthyl)propanoic acid

: 1310680-21-7
(S)-(-)-3-(tert-butoxycarbonyl)amino-(α-naphthyl)propanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 48h;
DOI:10.1002/1099-0690(200007)2000:13<2459::AID-EJOC2459>3.0.CO;2-D

Reference yield: 61.0%

: 180964-70-9
((R)-2-Naphthalen-1-yl-4,4-diphenyl-but-3-enyl)-carbamic acid tert-butyl ester

: 1310680-21-7
(S)-(-)-3-(tert-butoxycarbonyl)amino-(α-naphthyl)propanoic acid

Guidance literature:: With sodium periodate; ruthenium trichloride; In tetrachloromethane; acetonitrile; at 40 ℃; for 2h;
DOI:10.1039/a606586d

Reference yield:

: 86-87-3
naphth-1-yl acetic acid

: 1310680-21-7
(S)-(-)-3-(tert-butoxycarbonyl)amino-(α-naphthyl)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent

2: 70 percent / nBuLi; diisopropylamine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran; hexane / 17 h / -78 - 20 °C

3: 92 percent / H₂ / Pd(OH)2/C / ethyl acetate / 20 °C

4: 4-(dimethylamino)pyridine; dicyclohexylcarbodiimide / CH₂Cl₂ / 12 h / 20 °C

5: HCl; AcOH / Heating

6: 65 percent / NaOH / H₂O; tetrahydrofuran / 48 h / 20 °C

With hydrogenchloride; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hydroxide; n-butyllithium; hydrogen; acetic acid; diisopropylamine; dicyclohexyl-carbodiimide; palladium dihydroxide; In tetrahydrofuran; hexane; dichloromethane; water; ethyl acetate; 1: Esterification / 2: Alkylation / 3: Hydrogenolysis / 4: Esterification / 5: Hydrolysis / 6: Acylation;
DOI:10.1002/1099-0690(200007)2000:13<2459::AID-EJOC2459>3.0.CO;2-D