6-Methoxybenzo[d]isoxazole-3-carboxylic acid

Base Information

• Chemical Name: 6-Methoxybenzo[d]isoxazole-3-carboxylic acid
• CAS No.: 28691-48-7
• Molecular Formula: C9H7NO4
• Molecular Weight: 193.15618
• Hs Code.: 2934999090
• Mol file: 28691-48-7.mol

Synonyms:6-Methoxy-3-carboxybenzisoxazol;6-methoxy-3-azabicyclo<4.2.0>octan-2-one;

Chemical Property of 6-Methoxybenzo[d]isoxazole-3-carboxylic acid

Chemical Property:

• PSA: 72.56000
• LogP: 1.53460
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-Methoxybenzo[D]isoxazole-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Methoxybenzo[d]isoxazole-3-carboxylic acid

There total 3 articles about 6-Methoxybenzo[d]isoxazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2,4-dihydroxy-phenyl)-acetic acid ethyl ester (67828-62-0) → 6-Methoxy-3-carboxybenzisoxazol (28691-48-7)

Guidance literature:

Multi-step reaction with 3 steps

1: NH₂OSO₃H / H₂O

2: NaH / 1,2-dimethoxy-ethane

3: H₂SO₄

With sulfuric acid; sodium hydride; hydroxylamine-O-sulfonic acid; In 1,2-dimethoxyethane; water;

DOI:10.1021/ja00858a017

Reference yield:

6-hydroxy-benzo[d]isoxazole-3-carboxylic acid ethyl ester (57764-50-8) → 6-Methoxy-3-carboxybenzisoxazol (28691-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / 1,2-dimethoxy-ethane

2: H₂SO₄

With sulfuric acid; sodium hydride; In 1,2-dimethoxyethane;

DOI:10.1021/ja00858a017

Reference yield:

6-methoxy-benzo[d]isoxazole-3-carboxylic acid ethyl ester (57764-51-9) → 6-Methoxy-3-carboxybenzisoxazol (28691-48-7)

Guidance literature:

With sulfuric acid;

DOI:10.1021/ja00858a017

upstream raw materials:

6-methoxy-benzo[d]isoxazole-3-carboxylic acid ethyl ester

(2,4-dihydroxy-phenyl)-acetic acid ethyl ester

6-hydroxy-benzo[d]isoxazole-3-carboxylic acid ethyl ester