tert-Butyl 3-tert-butylpiperazine-1-carboxylate hydrochloride

Base Information

Chemical Name:tert-Butyl 3-tert-butylpiperazine-1-carboxylate hydrochloride
CAS No.:886779-61-9
Molecular Formula:C₁₃H₂₆N₂O₂
Molecular Weight:242.362
Hs Code.:
Mol file:886779-61-9.mol

Synonyms:tert-butyl 3-tert-butylpiperazine-1-carboxylate;tert-butyl 3-tert-butylpiperazine-1-carboxylate hydrochloride;1-Piperazinecarboxylic acid, 3-(1,1-dimethylethyl)-, 1,1-dimethylethyl ester;2-methyl-2-propanyl 3-(2-methyl-2-propanyl)-1-piperazinecarboxyla Te Hydrochloride (1:1)

Suppliers and Price of tert-Butyl 3-tert-butylpiperazine-1-carboxylate hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl3-(tert-butyl)piperazine-1-carboxylatehydrochloride 95+%
1g
$ 698.00

Chemenu
tert-Butyl3-(tert-butyl)piperazine-1-carboxylatehydrochloride 95%
1g
$ 660.00

American Custom Chemicals Corporation
3-TERT-BUTYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95.00%
5MG
$ 498.42

Alichem
tert-Butyl3-(tert-butyl)piperazine-1-carboxylatehydrochloride
1g
$ 579.36

Alichem
tert-Butyl3-(tert-butyl)piperazine-1-carboxylatehydrochloride
250mg
$ 301.74

Total 13 raw suppliers

Chemical Property of tert-Butyl 3-tert-butylpiperazine-1-carboxylate hydrochloride

Chemical Property:

Boiling Point:309.2±17.0 °C(Predicted)
PKA:8.52±0.40(Predicted)
PSA：41.57000
Density:0.981±0.06 g/cm3(Predicted)
LogP:3.31010

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-(tert-butyl)piperazine-1-carboxylatehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-Butyl 3-tert-butylpiperazine-1-carboxylate hydrochloride

There total 7 articles about tert-Butyl 3-tert-butylpiperazine-1-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₅₀N₂O₂Sn

: 886779-61-9
tert-butyl 3-(tert-butyl)piperazine-1-carboxylate

Guidance literature:: With 2,6-dimethylpyridine; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol500210z

Reference yield:

: 39684-80-5
2-(tert-butoxycarbonylamino)ethyl bromide

: 886779-61-9
tert-butyl 3-(tert-butyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 24 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2.2: 6 h / 0 - 20 °C

3.1: hydrazine / ethanol / 0.33 h / Reflux

4.1: dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

5.1: 2,6-dimethylpyridine; copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 12 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; copper(II) bis(trifluoromethanesulfonate); sodium hydride; hydrazine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol500210z

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 886779-61-9
tert-butyl 3-(tert-butyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

2.1: N,N-dimethyl-formamide / 24 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.2: 6 h / 0 - 20 °C

4.1: hydrazine / ethanol / 0.33 h / Reflux

5.1: dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

6.1: 2,6-dimethylpyridine; copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 12 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; copper(II) bis(trifluoromethanesulfonate); sodium hydride; triethylamine; hydrazine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol500210z