PF03084014

Base Information

Chemical Name:PF03084014
CAS No.:865773-15-5
Molecular Formula:C₂₇H₄₁F₂N₅O
Molecular Weight:489.652
Hs Code.:
Mol file:865773-15-5.mol

Synonyms:PF03084014;(2S)-2-[(6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl)amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide;Pentanamide, 2-[(6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl)amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]-, (2S)-

Suppliers and Price of PF03084014

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ApexBio Technology
PF-03084014
5mg
$ 117.00

Total 11 raw suppliers

Chemical Property of PF03084014

Chemical Property:

Boiling Point:651.3±55.0 °C(Predicted)
PKA:13.27±0.70(Predicted)
PSA：70.98000
Density:1.16±0.1 g/cm3(Predicted)
LogP:5.64120
Solubility.:≥19.8 mg/mL in DMSO

Purity/Quality:

98%,99%, ^*data from raw suppliers

PF-03084014 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of PF03084014

There total 10 articles about PF03084014 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 865774-07-8
2-methyl-2-(4-nitroimidazol-1-yl)propionic acid methyl ester

: 1290543-63-3,865773-15-5
PF-03084014

Guidance literature:: Multi-step reaction with 5 steps

1: diisobutylaluminium hydride / dichloromethane / -30 °C

2: dichloromethane / Molecular sieve

3: sodium tris(acetoxy)borohydride

4: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr

5: O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.12.118

Reference yield:

: 865774-76-1
2-Methyl-2-(4-nitro-imidazol-1-yl)-propionaldehyde

: 1290543-63-3,865773-15-5
PF-03084014

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / Molecular sieve

2: sodium tris(acetoxy)borohydride

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2068.65 Torr

4: O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.12.118

Reference yield:

: 843644-23-5
6,8-difluoro-3,4-dihydronaphthalen-2(1H)-one

: 1290543-63-3,865773-15-5
PF-03084014

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / dichloromethane

2: hydrogenchloride; water

3: O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.12.118