AG-024322

Base Information

• Chemical Name: AG-024322
• CAS No.: 837364-57-5
• Molecular Formula: C₂₃H₂₀F₂N₆
• Molecular Weight: 418.449
• Mol file: 837364-57-5.mol

Synonyms:UNII-926F8X7TNO;

Chemical Property of AG-024322

Chemical Property:

• Boiling Point: 668.4±65.0 °C(Predicted)
• PKA: 7.84±0.30(Predicted)
• PSA: 81.22000
• Density: 1.361±0.06 g/cm3(Predicted)
• LogP: 1.81600

Purity/Quality:

97% ^*data from raw suppliers

AG-024322 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AG-024322

There total 2 articles about AG-024322 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

{5-[3-(4,6-difluoro-1H-benzoimidazol-2-yl)-1-(tetrahydro-pyran-2-yl)-1H-indazol-5-yl]-4-methyl-pyridin-3-ylmethyl}-ethyl-carbamic acid tert-butyl ester (837364-62-2) → AG-024322 (837364-57-5)

Guidance literature:

{5-[3-(4,6-difluoro-1H-benzoimidazol-2-yl)-1-(tetrahydro-pyran-2-yl)-1H-indazol-5-yl]-4-methyl-pyridin-3-ylmethyl}-ethyl-carbamic acid tert-butyl ester; With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3.5h;

With ammonia; In cyclohexane; water; for 0.25h;

Reference yield: 74.0%

→ AG-024322 (837364-57-5)

Guidance literature:

upstream raw materials:

{5-[3-(4,6-difluoro-1H-benzoimidazol-2-yl)-1-(tetrahydro-pyran-2-yl)-1H-indazol-5-yl]-4-methyl-pyridin-3-ylmethyl}-ethyl-carbamic acid tert-butyl ester