CEP-32496

Base Information

• Chemical Name: CEP-32496
• CAS No.: 1227678-26-3
• Molecular Formula: C24H23ClF3N5O5
• Molecular Weight: 553.9181296
• Mol file: 1227678-26-3.mol

Synonyms:QCR-56;CS-1116;1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride;

Chemical Property of CEP-32496

Chemical Property:

• PSA: 127.35000
• LogP: 6.14870
• Solubility.: Soluble in DMSO

Purity/Quality:

97% ^*data from raw suppliers

CEP 32496 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CEP-32496

There total 3 articles about CEP-32496 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.6%

CEP-32496 (1188910-76-0) → 1-[3-(6,7-dimethoxy-quinazolin-4-yloxy)-phenyl]-3-[5-(2,2,2-trifluoro-1,1-dimethylethyl)isoxazol-3-yl]urea hydrochloride (1227678-26-3)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; Isopropyl acetate; isopropyl alcohol;

Reference yield:

phenyl (5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)carbamate (1188911-77-4) → 1-[3-(6,7-dimethoxy-quinazolin-4-yloxy)-phenyl]-3-[5-(2,2,2-trifluoro-1,1-dimethylethyl)isoxazol-3-yl]urea hydrochloride (1227678-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / Isopropyl acetate / 9 h / 70 °C / Inert atmosphere

2: hydrogenchloride / tetrahydrofuran; Isopropyl acetate; isopropyl alcohol

With hydrogenchloride; dmap; In tetrahydrofuran; Isopropyl acetate; isopropyl alcohol;

Reference yield:

3-(6,7-dimethoxyquinazolin-4-yloxy)-benzenamine (1188908-37-3) → 1-[3-(6,7-dimethoxy-quinazolin-4-yloxy)-phenyl]-3-[5-(2,2,2-trifluoro-1,1-dimethylethyl)isoxazol-3-yl]urea hydrochloride (1227678-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / Isopropyl acetate / 9 h / 70 °C / Inert atmosphere

2: hydrogenchloride / tetrahydrofuran; Isopropyl acetate; isopropyl alcohol

With hydrogenchloride; dmap; In tetrahydrofuran; Isopropyl acetate; isopropyl alcohol;

upstream raw materials:

CEP-32496

phenyl (5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)carbamate

3-(6,7-dimethoxyquinazolin-4-yloxy)-benzenamine