2-BROMO-4-FLUORO-5-METHYLBENZOIC ACID

Base Information

• Chemical Name: 2-BROMO-4-FLUORO-5-METHYLBENZOIC ACID
• CAS No.: 1003709-39-4
• Molecular Formula: C8H6BrFO2
• Molecular Weight: 233.037
• Hs Code.: 2916399090
• Mol file: 1003709-39-4.mol

Synonyms:Benzoic acid, 2-bromo-4-fluoro-5-methyl-

Chemical Property of 2-BROMO-4-FLUORO-5-METHYLBENZOIC ACID

Chemical Property:

• Boiling Point: 308.986 °C at 760 mmHg
• PKA: 2.86±0.10(Predicted)
• Flash Point: 140.67 °C
• PSA: 37.30000
• Density: 1.681 g/cm³
• LogP: 2.59480
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-bromo-4-fluoro-5-methylbenzoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-4-FLUORO-5-METHYLBENZOIC ACID

There total 1 articles about 2-BROMO-4-FLUORO-5-METHYLBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-bromo-4-fluoro-5-methylbenzaldehyde (916792-17-1) → 2-bromo-4-fluoro-5-methylbenzoic acid (1003709-39-4)

Guidance literature:

With sodium chlorite; potassium dihydrogenphosphate; aminosulfonic acid; In 1,4-dioxane; water; at 20 ℃;

Reference yield: 86.0%

2-bromo-4-fluoro-5-methylbenzoic acid (1003709-39-4) + 6-bromo-4-phenylisoquinolin-1(2H)-one → 6-bromo-2-(3-fluorophenyl)-4-phenylisoquinolin-1(2H)-one

Guidance literature:

With pyridine; copper diacetate; triethylamine; In dichloromethane; at 25 ℃; for 48h; Inert atmosphere;

Reference yield: 74.0%

2-bromo-4-fluoro-5-methylbenzoic acid (1003709-39-4) → 2-bromo-5-bromomethyl-4-fluorobenzoic acid (1610472-53-1)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In acetonitrile; for 4h; Reflux;

upstream raw materials:

2-bromo-4-fluoro-5-methylbenzaldehyde

Downstream raw materials:

6-tert-butyl-8-fluoro-2-[2-fluoro-5-hydroxymethyl-4-(2-oxo-1,2-dihydro-pyridin-4-yl)-benzyl]-2H-phthalazin-1-one

2-bromo-5-bromomethyl-4-fluorobenzoic acid

(2-bromo-5-bromomethyl-4-fluorophenyl)methanol

2-(4-bromo-2-fluoro-5-hydroxymethylbenzyl)-6-tert-butyl-8-fluoro-2H-phthalazin-1-one

Refernces