Methyl 3-amino-5-fluoro-4-methylbenzoate

Base Information

• Chemical Name: Methyl 3-amino-5-fluoro-4-methylbenzoate
• CAS No.: 1093087-06-9
• Molecular Formula: C9H10FNO2
• Molecular Weight: 183.182
• Hs Code.: 2922498590
• Mol file: 1093087-06-9.mol

Synonyms:EOS-60824;Methyl 3-aMino-5-fluoro-4-Methylbenzoate;3-Amino-5-fluoro-4-methyl methylbenzoate;3-Amino-5-fluoro-4-methylbenzoic acid methyl ester;Benzoic acid, 3-amino-5-fluoro-4-methyl-, methyl ester

Chemical Property of Methyl 3-amino-5-fluoro-4-methylbenzoate

Chemical Property:

• PSA: 52.32000
• LogP: 2.08410

Purity/Quality:

97% ^*data from raw suppliers

Methyl3-Amino-5-fluoro-4-methylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-amino-5-fluoro-4-methylbenzoate

There total 6 articles about Methyl 3-amino-5-fluoro-4-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-5-fluoro-4-methyl-3-nitro-benzoic acid methyl ester (1095005-99-4) → 3-amino-5-fluoro-4-methyl-benzoic acid methyl ester (1093087-06-9)

Guidance literature:

With ammonium formate; palladium-carbon; In ethanol; dichloromethane;

Reference yield:

2-chloro-5-fluoro-4-methyl-benzoic acid (103877-61-8) → 3-amino-5-fluoro-4-methyl-benzoic acid methyl ester (1093087-06-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium nitrate / conc sulfuric acid

2: chloro-trimethyl-silane / methanol

3: ammonium formate / palladium-carbon / dichloromethane; ethanol

With chloro-trimethyl-silane; ammonium formate; potassium nitrate; palladium-carbon; In methanol; conc sulfuric acid; ethanol; dichloromethane;

Reference yield:

2-chloro-5-fluoro-4-methyl-benzoic acid methyl ester (1095005-98-3) → 3-amino-5-fluoro-4-methyl-benzoic acid methyl ester (1093087-06-9)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide / methanol

2: potassium nitrate / conc sulfuric acid

3: chloro-trimethyl-silane / methanol

4: ammonium formate / palladium-carbon / dichloromethane; ethanol

With sodium hydroxide; chloro-trimethyl-silane; ammonium formate; potassium nitrate; palladium-carbon; In methanol; conc sulfuric acid; ethanol; dichloromethane;

upstream raw materials:

2-chloro-5-fluoro-4-methyl-3-nitro-benzoic acid methyl ester

2-chloro-5-fluoro-4-methyl-benzoic acid

2-chloro-5-fluoro-4-methyl-3-nitro-benzoic acid

2-chloro-5-fluoro-4-methyl-benzoic acid methyl ester

Downstream raw materials:

3-[(cyanomethyl)amino]-5-fluoro-4-methyl-benzoic acid, methyl ester

N-cyclopropyl-3-fluoro-5-[3-[[1-[2-[2-[(2-hydroxyethyl)amino]ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide

3-[5-bromo-3-[[1-methyl-1-[2-(phenylmethoxy)phenyl]ethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-5-fluoro-4-methyl-benzamide

N-cyclopropyl-3-[3-[[1-[2-[2-(ethylamino)ethoxy]phenyl]-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-5-fluoro-4-methyl-benzamide

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