2-Bromo-5-chloro-4-(trifluoromethyl)aniline

Base Information

• Chemical Name: 2-Bromo-5-chloro-4-(trifluoromethyl)aniline
• CAS No.: 863111-48-2
• Molecular Formula: C7H4BrClF3N
• Molecular Weight: 274.468
• Mol file: 863111-48-2.mol

Synonyms:LD-0705;2-bromo-5-chloro-4-trifluoromethyl-aniline;

Chemical Property of 2-Bromo-5-chloro-4-(trifluoromethyl)aniline

Chemical Property:

• Melting Point: 31-33°
• Boiling Point: 263.4±40.0 °C(Predicted)
• PKA: -0.36±0.10(Predicted)
• PSA: 26.02000
• Density: 1.789±0.06 g/cm3(Predicted)
• LogP: 4.28470
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-5-chloro-4-(trifluoromethyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-5-chloro-4-(trifluoromethyl)aniline

There total 2 articles about 2-Bromo-5-chloro-4-(trifluoromethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-bromo-2-chloro-4-nitrobenzotrifluoride (863111-47-1) → 2-bromo-5-chloro-4-trifluoromethyl-phenylamine (863111-48-2)

Guidance literature:

With iron; acetic acid; In 1,4-dioxane; water; at 60 ℃; for 0.5h;

Reference yield:

5-Amino-2-chloro-4-nitrobenzotrifluoride (167415-22-7) → 2-bromo-5-chloro-4-trifluoromethyl-phenylamine (863111-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen bromide; sodium nitrite / water / 4 h / -5 - 15 °C

2: iron; acetic acid / 1,4-dioxane; water / 0.5 h / 60 °C

With hydrogen bromide; iron; acetic acid; sodium nitrite; In 1,4-dioxane; water;

Reference yield: 99.0%

2-bromo-5-chloro-4-trifluoromethyl-phenylamine (863111-48-2) + di-tert-butyl dicarbonate (24424-99-5) → N-[2-bromo-5-chloro-4-(trifluoromethyl)phenyl]-N-[(2-methylpropan-2-yl)oxy carbonyl]butyl tertiary amine acid

Guidance literature:

With dmap; In tetrahydrofuran; at 20 ℃; for 2.5h;

upstream raw materials:

5-bromo-2-chloro-4-nitrobenzotrifluoride

5-Amino-2-chloro-4-nitrobenzotrifluoride

Downstream raw materials:

5-chloro-4-(trifluoromethyl)-2-[(trimethylsilyl)ethynyl]aniline

Refernces