16α-Methyl Prednisolone 21-Acetate

Base Information

• Chemical Name: 16α-Methyl Prednisolone 21-Acetate
• CAS No.: 13209-52-4
• Molecular Formula: C24H32O6
• Molecular Weight: 416.514
• Mol file: 13209-52-4.mol

Synonyms:[2-[(8S,9S,10R,11S,13S,14S,16R,17R)-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate;

Chemical Property of 16α-Methyl Prednisolone 21-Acetate

Chemical Property:

• Melting Point: 145-149 °C
• Boiling Point: 582.5±50.0 °C(Predicted)
• PKA: 12.43±0.70(Predicted)
• PSA: 100.90000
• Density: 1.26±0.1 g/cm3(Predicted)
• LogP: 2.37440
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

16α-MethylPrednisolone21-Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: an anti-inflammatory corticosteroid.

Technology Process of 16α-Methyl Prednisolone 21-Acetate

There total 9 articles about 16α-Methyl Prednisolone 21-Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C24H31BrO6 → 16α-Methyl-1,4-pregnadien-11β,17α,21-triol-3,20-dion-21-acetat (5078-99-9,6242-16-6,13209-52-4,18769-24-9,97274-92-5,97334-37-7)

Guidance literature:

With chromium chloride hexahydrate; mercaptoacetic acid; zinc; In N,N-dimethyl acetamide; at -10 - 0 ℃; Solvent; Inert atmosphere; Industrial scale;

Reference yield:

21-acetoxy-17-hydroxy-16α-methyl-pregn-4-ene-3,11,20-trione (34542-53-5) → 16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate (13209-52-4)

Guidance literature:

Multi-step reaction with 2 steps

1: SeO₂

2: ueber mehrere Stufen

With selenium(IV) oxide;

DOI:10.1021/ja01545a061

Reference yield:

21-acetoxy-17-hydroxy-16α-methyl-pregna-1,4-diene-3,11,20-trione (1058-04-4) → 16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate (13209-52-4)

Guidance literature:

ueber mehrere Stufen;

DOI:10.1021/ja01545a061

upstream raw materials:

21-acetoxy-17-hydroxy-16α-methyl-pregna-1,4-diene-3,11,20-trione

21-acetoxy-17-hydroxy-16α-methyl-pregn-4-ene-3,11,20-trione

Downstream raw materials:

alclometasone dipropionate

Refernces

• 1、 -. "Synthesis method of beclomethasone dipropionate intermediate 11 - β hydroxypregnane". Paragraph 0011; 0033; 0047-0065. . Retrieved 2020/10/30.