(2-fluoro-4-methoxyphenyl)hydrazine hydrochloride

Base Information

• Chemical Name: (2-fluoro-4-methoxyphenyl)hydrazine hydrochloride
• CAS No.: 940298-93-1
• Molecular Formula: C7H9FN2O·ClH
• Molecular Weight: 192.62
• Hs Code.: 2928000090
• Mol file: 940298-93-1.mol

Synonyms:(2-Fluoro-4-methoxyphenyl)hydrazine hydrochloride (1:1);

Chemical Property of (2-fluoro-4-methoxyphenyl)hydrazine hydrochloride

Chemical Property:

• Melting Point: 151-155 °C
• PSA: 47.28000
• LogP: 2.69520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(2-Fluoro-4-methoxyphenyl)hydrazine hydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-fluoro-4-methoxyphenyl)hydrazine hydrochloride

There total 2 articles about (2-fluoro-4-methoxyphenyl)hydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-fluoro-4-(methoxy)aniline (458-52-6) → (2-fluoro-4-methoxyphenyl)hydrazine hydrochloride (940298-93-1)

Guidance literature:

2-fluoro-4-(methoxy)aniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1.5h;

With hydrogenchloride; tin(ll) chloride; at 0 ℃; for 4h; Further stages.;

DOI:10.1016/j.jfluchem.2006.06.015

Reference yield: 51.0%

→ (2-fluoro-4-methoxyphenyl)hydrazine hydrochloride (940298-93-1)

Guidance literature:

With hydrogenchloride; tin(IV) chloride; sodium nitrite; In water; at 0 - 20 ℃; for 24h;

upstream raw materials:

2-fluoro-4-(methoxy)aniline

Refernces

• 1、 Brindani, Nicoletta,Gianotti, Ambra,Giovani, Simone,Giacomina, Francesca,Di Fruscia, Paolo,Sorana, Federico,Bertozzi, Sine Mandrup,Ottonello, Giuliana,Goldoni, Luca,Penna, Ilaria,Russo, Debora,Summa, Maria,Bertorelli, Rosalia,Ferrera, Loretta,Pesce, Emanuela,Sondo, Elvira,Galietta, Luis J. V.,Bandiera, Tiziano,Pedemonte, Nicoletta,Bertozzi, Fabio. "Identification, Structure-Activity Relationship, and Biological Characterization of 2,3,4,5-Tetrahydro-1 H-pyrido[4,3-b]indoles as a Novel Class of CFTR Potentiators". supporting information. p. 11169 - 11194. Retrieved 2020/10/09.
• 2、 Heredia-Moya, Jorge,Hayakawa, Yoshio,Kirk, Kenneth L.. "Syntheses of 7-fluoro- and 6,7-difluoroserotonin and 7-fluoro- and 6,7-difluoromelatonin". . p. 1256 - 1260. Retrieved 2008/12/20.