4-(Bromomethyl)-3-iodobenzonitrile

Base Information

• Chemical Name: 4-(Bromomethyl)-3-iodobenzonitrile
• CAS No.: 182287-63-4
• Molecular Formula: C8H5BrIN
• Molecular Weight: 321.943
• Hs Code.: 2926909090
• Mol file: 182287-63-4.mol

Synonyms:4-Cyano-2-iodobenzyl bromide;

Chemical Property of 4-(Bromomethyl)-3-iodobenzonitrile

Chemical Property:

• PSA: 23.79000
• LogP: 3.05778

Purity/Quality:

99% purity ^*data from raw suppliers

4-(Bromomethyl)-3-iodobenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Bromomethyl)-3-iodobenzonitrile

There total 1 articles about 4-(Bromomethyl)-3-iodobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

3-iodo-4-methylbenzonitrile (42872-79-7) → 4-bromomethyl-3-iodobenzonitrile (182287-63-4)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In 1,2-dichloro-ethane; Reflux; Inert atmosphere;

Reference yield: 99.0%

tert-butyl iminodiacetate (85916-13-8) + 4-bromomethyl-3-iodobenzonitrile (182287-63-4) → di-tert-butyl 2,2'-((4-cyano-2-iodobenzyl)azanediyl)diacetate

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃;

Reference yield: 84.0%

L-glycine tert butyl ester hydrochloride + 4-bromomethyl-3-iodobenzonitrile (182287-63-4) → tert-butyl 2-((4-cyano-2-iodobenzyl)amino)acetate

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃;

upstream raw materials:

3-iodo-4-methylbenzonitrile

Downstream raw materials:

5-[(4-cyano-2-iodobenzyloxy)-(4-cyanophenyl)methyl]-1-methyl-1H-imidazole

4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-(3,3-dimethyl-but-1-ynyl)-benzonitrile

4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-pyridin-2-ylethynyl-benzonitrile

4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-(4-nitro-phenylethynyl)-benzonitrile

Refernces

• 1、 -. "RADIOACTIVE HALOGEN LABELED COMPOUNDS OR SALTS THEREOF, AND PHARMACEUTICALS CONTAINING THE SAME". Paragraph 0077; 0078. . Retrieved 2018/12/12.