1-Bromo-3,5-dimethyl-4-iodobenzene

Base Information

• Chemical Name: 1-Bromo-3,5-dimethyl-4-iodobenzene
• CAS No.: 260355-37-1
• Molecular Formula: C8H8BrI
• Molecular Weight: 310.9576
• Mol file: 260355-37-1.mol

Synonyms:4-Bromo-2,6-dimethyliodobenzene; 5-Brom-2-iod-1,3-dimethylbenzol; Benzene, 5-bromo-2-iodo-1,3-dimethyl-; 5-Bromo-2-iodo-m-xylene; 1-Bromo-3,5-dimethyl-4-iodobenzene

Chemical Property of 1-Bromo-3,5-dimethyl-4-iodobenzene

Chemical Property:

• Vapor Pressure: 0.00573mmHg at 25°C
• Boiling Point: 282.4°C at 760 mmHg
• Flash Point: 124.6°C
• PSA: 0.00000
• Density: 1.94g/cm³
• LogP: 3.67050

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Bromo-3,5-dimethyl-4-iodobenzene

There total 2 articles about 1-Bromo-3,5-dimethyl-4-iodobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-bromo-2,6-dimethylphenylamine (24596-19-8) → 5-bromo-2-iodo-1,3-dimethyl-benzene (206559-43-5,260355-37-1)

Guidance literature:

4-bromo-2,6-dimethylphenylamine; With hydrogenchloride; at 0 ℃; for 0.5h;

With sodium nitrite; at 0 ℃; for 1h;

With potassium iodide; at 0 - 80 ℃; for 1.5h;

DOI:10.1021/acs.jmedchem.8b00557

Reference yield:

2,6-dimethylaniline (87-62-7) → 5-bromo-2-iodo-1,3-dimethyl-benzene (206559-43-5,260355-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bromine / dichloromethane / -78 °C / Inert atmosphere

2.1: sulfuric acid; sodium nitrite / water / 1 h / -10 °C

2.2: 20 °C

With sulfuric acid; bromine; sodium nitrite; In dichloromethane; water;

DOI:10.1039/d0cc03201h

Reference yield: 91.0%

allyl bromide (106-95-6) + 5-bromo-2-iodo-1,3-dimethyl-benzene (206559-43-5,260355-37-1) → 2,4-dimethyl-3-allylbromobenzene

Guidance literature:

5-bromo-2-iodo-1,3-dimethyl-benzene; With isopropylmagnesium chloride; In tetrahydrofuran; at -20 ℃; for 0.75h;

With copper(l) cyanide; lithium chloride; In tetrahydrofuran; at -20 - -10 ℃; for 0.5h;

allyl bromide; In tetrahydrofuran; at -10 ℃; for 0.166667h;

DOI:10.1002/anie.202105401

upstream raw materials:

4-bromo-2,6-dimethylphenylamine

2,6-dimethylaniline

Downstream raw materials:

ethyl 4-bromo-2,6-dimethylphenylphosphonamide

ethyl 2,6-dimethyl-4-naphthalen-2-ylphenylphosphonamide

5-(phenyl)sulfanyl-7-methyl-1,2-dihydro-1-ethoxy-3H-2,1-benzazaphosphol-3-one 1-oxide

7-methyl-5-phenyl-1,2-dihydro-1-ethoxy-3H-2,1-benzazaphosphol-3-one 1-oxide