Chemical Property of 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(pyrrolidin-1-yl)ethan-1-one
Chemical Property:
- Boiling Point:437.034 °C at 760 mmHg
- PKA:8.20±0.20(Predicted)
- Flash Point:218.111 °C
- PSA：25.24000
- Density:1.169 g/cm3
- LogP:3.44960
- Storage Temp.:Store at +4°C
- Solubility.:DMSO: >10mg/mL
- XLogP3:3.5
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:4
- Exact Mass:300.16379146
- Heavy Atom Count:22
- Complexity:389
- Purity/Quality:
-
99%, *data from raw suppliers
IU1 *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
41
- Safety Statements:
61
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3
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Description
IU1 (314245-33-5) is a selective inhibitor of USP14 (IC50<4 μM). Enhances proteasome activity and substrate proteolysis.1,2 Inhibits Dengue virus replication.3 In prion-infected CAD5 cells activation of the ubiquitin proteasome system by IU1 is sufficient to induce clearance of polyubiquitinated substrates and reduce misfolded prion protein load.4 Attenuates ischemia/reperfusion-induced neuronal injury in a mouse model.5 Cell permeable.
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Uses
IU1 has been used for the inhibition of Ubiquitin Specific Peptidase 14 (USP14) in human neuroblastoma cells (SH-SY5Y) and in ubiquitin-rhodamine hydrolysis plate assay.
