3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-N-(2-pyridinylmethyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridine-7-methanesulfonamide

Base Information

• Chemical Name: 3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-N-(2-pyridinylmethyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridine-7-methanesulfonamide
• CAS No.: 1001917-37-8
• Molecular Formula: C25H21N5O3S
• Molecular Weight: 471.53
• Mol file: 1001917-37-8.mol

Synonyms:3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-n-(2-pyridinylmethyl)-5H-benzo(4,5)cyclohepta(1,2-b)pyridine-7-methanesulfonamide;

Chemical Property of 3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-N-(2-pyridinylmethyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridine-7-methanesulfonamide

Chemical Property:

• Boiling Point: 761.011 °C at 760 mmHg
• PKA: 8.93±0.40(Predicted)
• Flash Point: 414.045 °C
• PSA: 115.22000
• Density: 1.394 g/cm³
• LogP: 4.63500

Purity/Quality:

98%Min ^*data from raw suppliers

MK8033 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: MK 8033 is a novel and specific dual ATP competitive c-Met/Ron inhibitor and is used in the treatment of cancer.

Technology Process of 3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-N-(2-pyridinylmethyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridine-7-methanesulfonamide

There total 2 articles about 3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-N-(2-pyridinylmethyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridine-7-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1-(3-chloro-5-oxo-5Hbenzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide (1001917-35-6) + lithium 2-hydroxy-4,4,5,5-tetramethyl-2-(1-methyl-1H-pyrazol-4-yl)-1,3,2-dioxaborolan-2-uide hydrate → MK-8033 (1001917-37-8,1196681-38-5)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In N,N-dimethyl-formamide; at 100 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm301619u

Reference yield:

1-(3-chloro-5-oxo-5Hbenzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide (1001917-35-6) + 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (761446-44-0) → MK-8033 (1001917-37-8,1196681-38-5)

Guidance literature:

1-(3-chloro-5-oxo-5Hbenzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide; 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; With potassium fluoride; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; at 130 ℃; for 6h;

With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

1-(3-chloro-5-oxo-5Hbenzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide

1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Refernces

• 1、 -. "Tyrosine kinase inhibitors". Page/Page column 53-54. . Retrieved 2009/01/23.