NEUROKININ B

Base Information

• Chemical Name: NEUROKININ B
• CAS No.: 86933-75-7
• Molecular Formula: C55H79N13O14S2
• Molecular Weight: 1210.44
• DSSTox Substance ID: DTXSID4040890
• Nikkaji Number: J260.381K
• Wikipedia: Neurokinin_B
• ChEMBL ID: CHEMBL437797
• Mol file: 86933-75-7.mol

Synonyms:NKB;NEUROMEDIN K;NEUROMEDIN K (HUMAN, PORCINE, BOVINE, RAT, MOUSE);NEUROKININ K;NEUROKININ BETA;NEUROKININ B (HUMAN, PORCINE);NEUROKININ B (HUMAN, PORCINE, BOVINE, RAT, MOUSE);NEUROKININ B

Chemical Property of NEUROKININ B

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.591
• Boiling Point: 1646 °C at 760 mmHg
• Flash Point: 949.3 °C
• PSA: 484.89000
• Density: 1.313 g/cm³
• LogP: 3.32120
• Storage Temp.: −20°C
• XLogP3: -1.6
• Hydrogen Bond Donor Count: 14
• Hydrogen Bond Acceptor Count: 18
• Rotatable Bond Count: 38
• Exact Mass: 1209.53108659
• Heavy Atom Count: 84
• Complexity: 2220

Purity/Quality:

98%,99%, ^*data from raw suppliers

NKB ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)N
• Isomeric SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC3=CN=CN3)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)N
• Biological functions: In mammals, NK3 is distributed in the brain, hypothalamus (including the median eminence), kidney, lung, placenta, prostate, testis, muscle, intestine, uterus, and the sperm midpiece as well as weakly in the proximal region of the sperm flagellum. In zebrafish, tacr3a is expressed mainly in the pituitary, also during embryonic development. A low tacr3b expression was detected in the midbrain and testis. In mammals, circulating NKB via the enhancement of expression of the tac3 gene was elevated in the placenta of preeclampsia women, but not in the placenta of women in normotensive pregnancy. Moreover, NKB participates in the regulation of GnRH pulse generation in the mammalian hypothalamus-pituitary-gonad axis. This GnRH release system is in part regulated by NKB in concert with kisspeptin yielded by KNDy neurons, whereas the involvement of non-KNDy NKB neurons or other kisspeptin-free NKB neurons in the stimulation of GnRH release is also reported. NK3R is also suggested to influence alcohol intake and behavioral/neurochemical responses to cocaine. In prepubertal zebrafish, estradiol treatment upregulates tac3a gene expression as well as kiss1, kiss2, and gnrh3.? Furthermore, in sexually mature zebrafish, the intraperitoneal injection of NKBa and NKF resulted in the secretion of luteinizing hormone.
• Description: Vertebrate tachykinins encoded by TAC3 gene (Tac2 in rodents). In 1983, Kangawa et al. isolated neurokinin B (NKB) from the porcine spinal cord and elucidated the primary sequence as Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-amide, followed by the characterization of other tetrapod NKB. In 2012, teleost NKB and its-gene-related peptide, NKF, were identified.

Technology Process of NEUROKININ B

There total 1 articles about NEUROKININ B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C81H105N13O18S3 → neurokinin B (86933-75-7)

Guidance literature:

With hydrogen fluoride; methoxybenzene; In dimethyl sulfoxide; at 0 ℃; for 1h;

DOI:10.1246/cl.1984.1013

Reference yield:

copper(II) choride dihydrate + H-DMHDFFVGLM-NH2 (86933-75-7) → CuII(NKB)2

Guidance literature:

With N-ethylmorpholine;; sodium dodecyl-sulfate; In water; pH=7.6; pH-value;

DOI:10.1021/cn4000988

Refernces