2-Chloro-6-(trifluoromethyl)nicotinaldehyde

Base Information

• Chemical Name: 2-Chloro-6-(trifluoromethyl)nicotinaldehyde
• CAS No.: 944900-06-5
• Molecular Formula: C₇H₃ClF₃NO
• Molecular Weight: 209.555
• Hs Code.: 2933399990
• Mol file: 944900-06-5.mol

Synonyms:2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINALDEHYDE;2-CHLORO-6-TRIFLUOROMETHYL-PYRIDINE-3-CARBALDEHYDE

Chemical Property of 2-Chloro-6-(trifluoromethyl)nicotinaldehyde

Chemical Property:

• Vapor Pressure: 0.087mmHg at 25°C
• Boiling Point: 225.301°C at 760 mmHg
• Flash Point: 90.059°C
• PSA: 29.96000
• Density: 1.499g/cm³
• LogP: 2.56630
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-6-(trifluoromethyl)nicotinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-6-(trifluoromethyl)nicotinaldehyde

There total 5 articles about 2-Chloro-6-(trifluoromethyl)nicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-chloro-6-trifluoromethylpyridine (39890-95-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-chloro-6-(trifluoromethyl)pyridine-3-carbaldehyde (944900-06-5)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃;

DOI:10.1016/j.bmcl.2013.12.106

Reference yield: 81.0%

[2-chloro-6-(trifluoromethyl)pyridin-3-yl]methanol (917396-39-5) → 2-chloro-6-(trifluoromethyl)pyridine-3-carbaldehyde (944900-06-5)

Guidance literature:

With silica gel; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 3h;

Reference yield: 33.3%

2-chloro-6-(trifluoromethyl)nicotinonitrile (386704-06-9) → 2-chloro-6-(trifluoromethyl)pyridine-3-carbaldehyde (944900-06-5)

Guidance literature:

2-chloro-6-(trifluoromethyl)nicotinonitrile; With diisobutylaluminium hydride; In toluene; at -78 ℃; Inert atmosphere;

With acetic acid; In water; toluene; at 0 ℃; for 2h; Product distribution / selectivity;

upstream raw materials:

2-chloro-6-(trifluoromethyl)nicotinonitrile

[2-chloro-6-(trifluoromethyl)pyridin-3-yl]methanol

2-chloro-6-trifluoromethylpyridine

2-chloro-6-(trifluoromethyl)pyridine-3-carboxylic acid

Refernces

• 1、 -. "COMPOUNDS WITH NEMATICIDAL ACTIVITY". Page/Page column 127. . Retrieved 2013/05/22.
• 2、 -. "FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE". Page/Page column 105-106. . Retrieved 2010/08/08.