1-(3-Methoxyphenyl)cyclopentanecarbonitrile

Base Information

• Chemical Name: 1-(3-Methoxyphenyl)cyclopentanecarbonitrile
• CAS No.: 74316-83-9
• Molecular Formula: C₁₃H₁₅NO
• Molecular Weight: 201.268
• Hs Code.: 2926909090
• Mol file: 74316-83-9.mol

Synonyms:Cyclopentanecarbonitrile, 1-(3-methoxyphenyl)-;

Chemical Property of 1-(3-Methoxyphenyl)cyclopentanecarbonitrile

Chemical Property:

• Refractive Index: 1.5365 (589.3 nm 22℃)
• PSA: 33.02000
• LogP: 3.03058
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-(3-Methoxyphenyl)cyclopentanecarbonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-Methoxyphenyl)cyclopentanecarbonitrile

There total 2 articles about 1-(3-Methoxyphenyl)cyclopentanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.5%

1,4-dibromo-butane (110-52-1) + 3-methoxyphenylacetonitrile (19924-43-7) → 1-(3-Methoxyphenyl)cyclopentanecarbonitrile (74316-83-9)

Guidance literature:

With sodium hydroxide; at 110 - 120 ℃; for 12h;

DOI:10.1007/BF00777383

Reference yield:

→ 1-(3-Methoxyphenyl)cyclopentanecarbonitrile (74316-83-9)

Guidance literature:

3-Methoxy-benzylcyanid, 1,4-Dibrom-butan, NaOH, 100-110grad;

Reference yield: 62.5%

1-(3-Methoxyphenyl)cyclopentanecarbonitrile (74316-83-9) → 1-(m-Methoxyphenyl)-cyclopentancarbonsaeure (43050-39-1)

Guidance literature:

With potassium hydroxide; In diethylene glycol; for 6h; Heating;

DOI:10.1007/BF00777383

upstream raw materials:

1,4-dibromo-butane

3-methoxyphenylacetonitrile

Downstream raw materials:

C-[1-(3-Methoxy-phenyl)-cyclopentyl]-methylamine

1-(m-Methoxyphenyl)-cyclopentancarbonsaeure

(2S,5R,6R)-6-{[1-(3-Methoxy-phenyl)-cyclopentanecarbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

Ethyl-[1-(3-methoxy-phenyl)-cyclopentylmethyl]-amine

Refernces

• 1、 Mndzhoyan, Sh. L.,Tsinker, M. G.,Ovakimyan, A. R.,Ter-Zakharyan, Yu. Z.,Oganyan, Sh. G.. "INVESTIGATIONS IN THE FIELD OF SEMISYNTHETIC PENICILLINS. XIV. 1-(ALKOXYPHENYL)CYCLOPENTYL-1-PENICILLINS". . p. 179 - 184. Retrieved 2007/10/02.