2-(4-BROMOPHENYL)IMIDAZO[1,2-A]PYRIDIN-6-YLAMINE

Base Information

• Chemical Name: 2-(4-BROMOPHENYL)IMIDAZO[1,2-A]PYRIDIN-6-YLAMINE
• CAS No.: 885950-52-7
• Molecular Formula: C13H10BrN3
• Molecular Weight: 288.147
• Hs Code.: 2933990090
• Mol file: 885950-52-7.mol

Synonyms:bromophenylimidazopyridinylamine;2-(4-Bromophenyl)imidazo[1,2-a]pyridin-6-ylamine;

Chemical Property of 2-(4-BROMOPHENYL)IMIDAZO[1,2-A]PYRIDIN-6-YLAMINE

Chemical Property:

• Melting Point: 191-195°C
• PSA: 43.32000
• LogP: 3.92720

Purity/Quality:

98%min ^*data from raw suppliers

6-Amino-2-(4-bromophenyl)imidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-BROMOPHENYL)IMIDAZO[1,2-A]PYRIDIN-6-YLAMINE

There total 4 articles about 2-(4-BROMOPHENYL)IMIDAZO[1,2-A]PYRIDIN-6-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2-(4-bromophenyl)-6-nitroimidazo[1,2-a]pyridine (118000-56-9) → 2-(4-bromophenyl)imidazo[1,2-a]pyridin-6-amine (885950-52-7)

Guidance literature:

With iron; ammonium chloride; In tetrahydrofuran; methanol; water; at 50 ℃; for 16h;

Reference yield:

5-nitro-pyridin-2-ylamine (4214-76-0,67476-67-9) → 2-(4-bromophenyl)imidazo[1,2-a]pyridin-6-amine (885950-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 2)HBr / 1) acetone, reflux, 3 h, 2) methanol, reflux, 60 min

2: 1) SnCl₂*2H₂O, conc. HCl / 1 h / Ambient temperature

With hydrogenchloride; hydrogen bromide; tin(ll) chloride;

DOI:10.1002/jhet.5570250119

Reference yield:

para-bromophenacyl bromide (99-73-0,132309-76-3) → 2-(4-bromophenyl)imidazo[1,2-a]pyridin-6-amine (885950-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / acetonitrile / 3 h / 80 °C

2: iron; ammonium chloride / water; methanol; tetrahydrofuran / 16 h / 50 °C

With iron; sodium hydrogencarbonate; ammonium chloride; In tetrahydrofuran; methanol; water; acetonitrile;

upstream raw materials:

2-(4-bromophenyl)-6-nitroimidazo[1,2-a]pyridine

5-nitro-pyridin-2-ylamine

para-bromophenacyl bromide

Downstream raw materials:

2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]imidazo[1,2-a]pyridin-6-amine

N-[2-(4-Cyano-phenyl)-imidazo[1,2-a]pyridin-6-yl]-acetamide

N-[2-(4-Formyl-phenyl)-imidazo[1,2-a]pyridin-6-yl]-acetamide