(S)-2-Methylmorpholine hcl

Base Information

• Chemical Name: (S)-2-Methylmorpholine hcl
• CAS No.: 1147108-99-3
• Molecular Formula: C5H11NO^.HCl
• Molecular Weight: 137.609
• Hs Code.: 2934999090
• Mol file: 1147108-99-3.mol

Synonyms:(2S)-2-Methylmorpholine hydrochloride (1:1);

Chemical Property of (S)-2-Methylmorpholine hcl

Chemical Property:

• PSA: 21.26000
• LogP: 1.12550
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(2S)-2-Methylmorpholine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-Methylmorpholine hcl

There total 2 articles about (S)-2-Methylmorpholine hcl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-methyl-4-(4-nitrobenzenesulfonyl)morpholine → (2S)-2-methylmorpholine hydrochloride (1147108-99-3,168038-14-0,59229-57-1)

Guidance literature:

(S)-2-methyl-4-(4-nitrobenzenesulfonyl)morpholine; With lithium hydroxide monohydrate; 1-thiopropane; In acetonitrile; at 20 ℃;

With hydrogenchloride; In methanol; acetonitrile;

Reference yield:

(S)-(benzyl(2-hydroxyethyl)amino)propan-2-ol → (2S)-2-methylmorpholine hydrochloride (1147108-99-3,168038-14-0,59229-57-1)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; palladium on activated charcoal / methanol / 1 h / 20 °C / 760.05 Torr

2: triethylamine / dichloromethane / 20 °C

3: lithium hydroxide monohydrate; 1-thiopropane / acetonitrile / 20 °C

With lithium hydroxide monohydrate; 1-thiopropane; palladium on activated charcoal; hydrogen; triethylamine; In methanol; dichloromethane; acetonitrile;

Reference yield:

5-chloro-2-fluoro-4-iodopyridine (659731-48-3) + (2S)-2-methylmorpholine hydrochloride (1147108-99-3,168038-14-0,59229-57-1) → C10H12ClIN2O

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃; for 18h;

Refernces