DL-TRYPTOPHAN-2,3,3-D3

Base Information

• Chemical Name: DL-TRYPTOPHAN-2,3,3-D3
• CAS No.: 340257-61-6
• Molecular Formula: CH3CH=C(CH3)CONHCD2COOH
• Molecular Weight: 238.77
• Mol file: 340257-61-6.mol

Synonyms:1H-Indole-3-alanine-d3;D,L-Tryptophan-d3;DL-|A-Amino-3-indolepropionic Acid-d3;

Chemical Property of DL-TRYPTOPHAN-2,3,3-D3

Chemical Property:

• Melting Point: 248-250°C (dec.)
• PSA: 79.11000
• LogP: 1.82260
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated), Water (Slightly

Purity/Quality:

98% ^*data from raw suppliers

D,L-Tryptophan-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A labelled, essential amino acid.

Technology Process of DL-TRYPTOPHAN-2,3,3-D3

There total 2 articles about DL-TRYPTOPHAN-2,3,3-D3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

indole (120-72-9) + paraformaldehyde-d2 (1664-98-8,43094-80-0) + 2-(13)C-glycine (20220-62-6) → (2-13C, 2, 3, 3-2H3)-L-tryptophan (340257-61-6)

Guidance literature:

With pyridoxal 5'-phosphate; water-d2; L-threonine aldolase from thermatoga maritima; TrpB^2B₉ protein from the hyperthermophilicarcheon Pyrococcus furiosus; In aq. phosphate buffer; at 50 - 90 ℃; Sealed tube; Enzymatic reaction;

DOI:10.1039/d0ob00868k

Reference yield:

indole (120-72-9) + ammonium pyruvate → α,β,β-tri-2H-L-tryptophan (340257-61-6)

Guidance literature:

ammonium pyruvate; With ammonium sulfate; water-d2; at 20 ℃; for 168000h;

indole; With tryptophan indole-lyase EC 4.1.99.1; pyridoxal 5'-phosphate; water-d2; at 20 ℃; for 336000h; pH=8.35; Further stages.;

DOI:10.1021/ja991647q

upstream raw materials:

indole

paraformaldehyde-d2

2-⁽¹³⁾C-glycine

Refernces

• 1、 Phillips, Robert S.,Sundararaju, Bakthavatsalam,Faleev, Nicolai G.. "Proton transfer and carbon-carbon bond cleavage in the elimination of indole catalyzed by Escherichia coli tryptophan indole-lyase". . p. 1008 - 1014. Retrieved 2007/10/03.