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Technology Process of DL-Valine-d8

DL-Valine-d8

Base Information
  • Chemical Name:DL-Valine-d8
  • CAS No.:203784-63-8
  • Molecular Formula:(CD3)2CDCD(NH2)COOH
  • Molecular Weight:187.8
  • Hs Code.:
  • DSSTox Substance ID:DTXSID40514732
  • Mol file:203784-63-8.mol
DL-Valine-d8

Synonyms:DL-Valine-d8;203784-63-8;DL-Valine-2,3,4,4,4,5,5,5-d8;2-amino-2,3,4,4,4-pentadeuterio-3-(trideuteriomethyl)butanoic acid;SCHEMBL2557671;DL-Valine-d8, 98 atom % D;DTXSID40514732;HY-W012889S;CS-0376477;D98944;J-013255;(2,3,4,4,4,4',4',4'-~2~H_8_)Valine;2-amino-2, 3, 4, 4, 4-pentadeuterio-3-(trideuteriomethyl)butanoic acid

Suppliers and Price of DL-Valine-d8
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Sigma-Aldrich
  • DL-Valine-d8 98 atom % D
  • 1g
  • $ 638.00
  • Medical Isotopes, Inc.
  • DL-Valine-d8
  • 1 g
  • $ 1585.00
  • American Custom Chemicals Corporation
  • DL-VALINE-D8 95.00%
  • 5MG
  • $ 496.84
Total 8 raw suppliers
Chemical Property of DL-Valine-d8
Chemical Property:
  • Vapor Pressure:0.0633mmHg at 25°C 
  • Melting Point:295oC (subl.)(lit.) 
  • Boiling Point:213.6oC at 760 mmHg 
  • Flash Point:83oC 
  • PSA：63.32000 
  • Density:1.136g/cm3 
  • LogP:0.75460 
  • XLogP3:-2.3
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:2
  • Exact Mass:125.129192561
  • Heavy Atom Count:8
  • Complexity:90.4
Purity/Quality:

99%, *data from raw suppliers

DL-Valine-d8 98 atom % D *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC(C)C(C(=O)O)N
  • Isomeric SMILES:[2H]C([2H])([2H])C([2H])(C([2H])([2H])[2H])C([2H])(C(=O)O)N
  • Uses DL-Valine-d8 (CAS# 203784-63-8) is a useful isotopically labeled research compound.
Technology Process of DL-Valine-d8

There total 1 articles about DL-Valine-d8 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C<sub>5</sub>H<sub>2</sub><sup>(2)</sup>H<sub>8</sub>N<sub>2</sub>

C5H2(2)H8N2

[2,3,4,4,4,4',4',4'-(2)H8]valine
203784-63-8,83181-79-7

[2,3,4,4,4,4',4',4'-(2)H8]valine

Guidance literature:
With hydrogenchloride; water; for 12h; Reflux;
DOI:10.1002/cbdv.201000158

Reference yield:

L-valine-d<sub>8</sub>
203784-63-8,83181-79-7

L-valine-d8

S-2-((S)-3-(4-chlorophenyl)-N'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-(methyl-d<SUB>3</SUB>)butanamide-d<SUB>5</SUB>

S-2-((S)-3-(4-chlorophenyl)-N'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-(methyl-d3)butanamide-d5

C<sub>27</sub>H<sub>19</sub><sup>(2)</sup>H<sub>8</sub>Cl<sub>2</sub>N<sub>5</sub>O<sub>3</sub>S

C27H19(2)H8Cl2N5O3S

Guidance literature:
Multi-step reaction with 3 steps
1: thionyl chloride / methanol / -20 - 65 °C
2: ammonium hydroxide / methanol / 24 h / 65 °C
3: triethylamine / methanol; dichloromethane / 5 h / 20 °C / Cooling
With ammonium hydroxide; thionyl chloride; triethylamine; In methanol; dichloromethane;
DOI:10.1002/jlcr.3521
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