Ethyl trans-Cinnamate-d5

Base Information

Chemical Name:Ethyl trans-Cinnamate-d5
CAS No.:856765-68-9
Molecular Formula:C6D5CH=CHCOOCH2CH3
Molecular Weight:181.25
Hs Code.:
Mol file:856765-68-9.mol

Synonyms:Ethyl trans-Cinnamate-d5;

Suppliers and Price of Ethyl trans-Cinnamate-d5

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Ethyl trans-Cinnamate-d5
25mg
$ 425.00

TRC
Ethyltrans-Cinnamate-d5
250mg
$ 800.00

Medical Isotopes, Inc.
Ethyltrans-cinnamate-d5
500 mg
$ 690.00

Total 2 raw suppliers

Chemical Property of Ethyl trans-Cinnamate-d5

Chemical Property:

PSA：26.30000
LogP:2.26290

Purity/Quality:

97% ^*data from raw suppliers

Ethyl trans-Cinnamate-d5 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (Ethyl trans-CinnaMate-d5) Isotope labelled Ethyl trans-Cinnamate, used in the preparation of polymer-encapsulated osmonium used as a catalyst for the dihydroxylation of alkenes and preparation of a camptothecin intermediate, anticancer drug. Also used in the synthesis of substrate specific ERK1/2 inhibitors used to induce apoptosis and inhibit cell proliferation.

Technology Process of Ethyl trans-Cinnamate-d5

There total 2 articles about Ethyl trans-Cinnamate-d5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 14132-51-5
2,3,4,5,6-pentadeuteriobenzaldehyde

: 856765-68-9
3-[2H₅]phenylacrylic acid ethyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1002/jlcr.870

Reference yield:

: 4165-57-5
bromobenzene-d5

: 856765-68-9
3-[2H₅]phenylacrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: BuLi / -78 °C

1.3: HCl / H₂O

2.1: 92 percent / NaH / dimethylformamide

With n-butyllithium; sodium hydride; In N,N-dimethyl-formamide; 2.1: Wittig homologation;
DOI:10.1002/jlcr.870

Reference yield:

: 856765-68-9
3-[2H₅]phenylacrylic acid ethyl ester

: 856765-70-3
4S-benzyl-3-(3-[2H₅]phenyl-propionyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: LiOH / methanol

1.2: HCl

2.1: 4-methylmorpholine / tetrahydrofuran / cooling

3.1: BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

4.1: 17.10 g / hydrogen / Pd/C / ethyl acetate / 3 h

With 4-methyl-morpholine; lithium hydroxide; n-butyllithium; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; ethyl acetate;
DOI:10.1002/jlcr.870